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10.1007/s11888-017-0354-9

http://scihub22266oqcxt.onion/10.1007/s11888-017-0354-9
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C5391049!5391049!28413363
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suck abstract from ncbi

pmid28413363      Curr+Colorectal+Cancer+Rep 2017 ; 13 (2): 101-10
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  • Wnt Signaling and Colorectal Cancer #MMPMID28413363
  • Schatoff EM; Leach BI; Dow LE
  • Curr Colorectal Cancer Rep 2017[Apr]; 13 (2): 101-10 PMID28413363show ga
  • The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.
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