Wnt Signaling and Colorectal Cancer #MMPMID28413363
Schatoff EM; Leach BI; Dow LE
Curr Colorectal Cancer Rep 2017[Apr]; 13 (2): 101-10 PMID28413363show ga
The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.