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10.1016/j.celrep.2016.04.006 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.006 C5391032!5391032!27134165     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (6): 1291-302 Nephropedia Template TP {{tp|p=27134165|t=2016. EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling |pdf=|usr=}}{{27134165}} gab.com Text EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27134165 #FOAvip Delineating the crosstalk between distinct signaling pathways is key to understanding the diverse and dynamic responses of adult stem cells during tissue regeneration. Here we demonstrate that the Edn/EdnrB signaling pathway can interact with other signaling pathways to elicit distinct stem cell functions during tissue regeneration. EdnrB signaling promotes proliferation and differentiation of melanocyte stem cells (McSCs), dramatically enhancing the regeneration of hair and epidermal melanocytes. This effect is dependent upon active Wnt signaling that is initiated by Wnt ligand secretion from the hair follicle epithelial niche. Further, this Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. This suggests that targeting Edn/EdnrB signaling in McSCs can be a therapeutic approach to promote photoprotective-melanocyte regeneration, which may be useful for those with increased risk of skin cancers due to Mc1R variants. Twit Text FOAVip EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27134165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27134165 #FOAvip English Wikipedia <ref>{{Cite pmid|27134165}}</ref> EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling #MMPMID27134165 Takeo M; Lee W; Rabbani P; Sun Q; Hu H; Lim CH; Manga P; Ito M Cell Rep 2016[May]; 15 (6): 1291-302 PMID27134165show ga Delineating the crosstalk between distinct signaling pathways is key to understanding the diverse and dynamic responses of adult stem cells during tissue regeneration. Here we demonstrate that the Edn/EdnrB signaling pathway can interact with other signaling pathways to elicit distinct stem cell functions during tissue regeneration. EdnrB signaling promotes proliferation and differentiation of melanocyte stem cells (McSCs), dramatically enhancing the regeneration of hair and epidermal melanocytes. This effect is dependent upon active Wnt signaling that is initiated by Wnt ligand secretion from the hair follicle epithelial niche. Further, this Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. This suggests that targeting Edn/EdnrB signaling in McSCs can be a therapeutic approach to promote photoprotective-melanocyte regeneration, which may be useful for those with increased risk of skin cancers due to Mc1R variants. äEdnrB governs regenerative response of melanocyte stem cells by crosst(epmc).pdf DeepDyve Pubget Overpricing