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10.1161/CIRCHEARTFAILURE.116.003612 http://scihub22266oqcxt.onion/10.1161/CIRCHEARTFAILURE.116.003612 C5390814!5390814!28396500     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Heart+Fail 2017 ; 10 (4): e003612 Nephropedia Template TP {{tp|p=28396500|t=2017. Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure with Preserved Ejection Fraction |pdf=|usr=}}{{28396500}} gab.com Text Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure with Preserved Ejection Fraction JO: Circ Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=28396500 #FOAvip Background: People with heart failure and preserved ejection fraction (HFpEF) develop increases in left ventricular (LV) end-diastolic pressures (LVEDP) during exercise that contribute to dyspnea. In normal open-chest animal preparations, the pericardium restrains LV filling when central blood volume increases. We hypothesized that resection of the pericardium using a minimally-invasive epicardial approach would mitigate the increase in LVEDP that develops during volume loading in normal and diseased hearts with the chest intact. Methods and Results: Invasive hemodynamic assessment was performed at baseline and following saline load before and after pericardial resection in normal canines with open (n=3) and closed chest (n=5) and in a pig model with features of human HFpEF with sternum intact (n=4). In closed-chest animals, pericardiotomy was performed using a novel subxiphoid procedure. In both experimental preparations of normal dogs, pericardiotomy blunted the increase in LVEDP with saline infusion, while enhancing the saline-mediated increase in LV end-diastolic volume (LVEDV). With chest intact in the pig model, percutaneous pericardial resection again blunted the increase in LVEDP secondary to volume expansion (+4±3 vs +13±5 mmHg, p=0.014) while enhancing the saline-mediated increase in LVEDV (+17±1 vs +10±2 ml, p=0.016). Conclusions: This proof of concept study demonstrates that pericardial resection through a minimally-invasive percutaneous approach mitigates the elevation in LV filling pressures with volume loading in both normal animals and a pig model with diastolic dysfunction. Further study is warranted to determine whether this method is safe and produces similar acute and chronic hemodynamic benefits in people with HFpEF. Twit Text FOAVip Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure with Preserved Ejection Fraction ????Circ Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=28396500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28396500 #FOAvip English Wikipedia <ref>{{Cite pmid|28396500}}</ref> Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure with Preserved Ejection Fraction #MMPMID28396500 Borlaug BA; Carter RE; Melenovsky V; De Simone CV; Gaba P; Killu A; Naksuk N; Lerman L; Asirvatham SJ Circ Heart Fail 2017[Apr]; 10 (4): e003612 PMID28396500show ga Background: People with heart failure and preserved ejection fraction (HFpEF) develop increases in left ventricular (LV) end-diastolic pressures (LVEDP) during exercise that contribute to dyspnea. In normal open-chest animal preparations, the pericardium restrains LV filling when central blood volume increases. We hypothesized that resection of the pericardium using a minimally-invasive epicardial approach would mitigate the increase in LVEDP that develops during volume loading in normal and diseased hearts with the chest intact. Methods and Results: Invasive hemodynamic assessment was performed at baseline and following saline load before and after pericardial resection in normal canines with open (n=3) and closed chest (n=5) and in a pig model with features of human HFpEF with sternum intact (n=4). In closed-chest animals, pericardiotomy was performed using a novel subxiphoid procedure. In both experimental preparations of normal dogs, pericardiotomy blunted the increase in LVEDP with saline infusion, while enhancing the saline-mediated increase in LV end-diastolic volume (LVEDV). With chest intact in the pig model, percutaneous pericardial resection again blunted the increase in LVEDP secondary to volume expansion (+4±3 vs +13±5 mmHg, p=0.014) while enhancing the saline-mediated increase in LVEDV (+17±1 vs +10±2 ml, p=0.016). Conclusions: This proof of concept study demonstrates that pericardial resection through a minimally-invasive percutaneous approach mitigates the elevation in LV filling pressures with volume loading in both normal animals and a pig model with diastolic dysfunction. Further study is warranted to determine whether this method is safe and produces similar acute and chronic hemodynamic benefits in people with HFpEF. äPercutaneous Pericardial Resection: A Novel Potential Treatment for He(epmc).pdf DeepDyve Pubget Overpricing