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10.1093/scan/nsw173 http://scihub22266oqcxt.onion/10.1093/scan/nsw173 C5390724!5390724!28119505     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Soc+Cogn+Affect+Neurosci 2017 ; 12 (4): 651-61 Nephropedia Template TP {{tp|p=28119505|t=2017. Orbitofrontal cortex mediates pain inhibition by monetary reward |pdf=|usr=}}{{28119505}} gab.com Text Orbitofrontal cortex mediates pain inhibition by monetary reward JO: Soc Cogn Affect Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28119505 #FOAvip Pleasurable stimuli, including reward, inhibit pain, but the level of the neuraxis at which they do so and the cerebral processes involved are unknown. Here, we characterized a brain circuitry mediating pain inhibition by reward. Twenty-four healthy participants underwent functional magnetic resonance imaging while playing a wheel of fortune game with simultaneous thermal pain stimuli and monetary wins or losses. As expected, winning decreased pain perception compared to losing. Inter-individual differences in pain modulation by monetary wins relative to losses correlated with activation in the medial orbitofrontal cortex (mOFC). When pain and reward occured simultaneously, mOFCs functional connectivity changed: the signal time course in the mOFC condition-dependent correlated negatively with the signal time courses in the rostral anterior insula, anterior-dorsal cingulate cortex and primary somatosensory cortex, which might signify moment-to-moment down-regulation of these regions by the mOFC. Monetary wins and losses did not change the magnitude of pain-related activation, including in regions that code perceived pain intensity when nociceptive input varies and/or receive direct nociceptive input. Pain inhibition by reward appears to involve brain regions not typically involved in nociceptive intensity coding but likely mediate changes in the significance and/or value of pain. Twit Text FOAVip Orbitofrontal cortex mediates pain inhibition by monetary reward ????Soc Cogn Affect Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28119505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28119505 #FOAvip English Wikipedia <ref>{{Cite pmid|28119505}}</ref> Orbitofrontal cortex mediates pain inhibition by monetary reward #MMPMID28119505 Becker S; Gandhi W; Pomares F; Wager TD; Schweinhardt P Soc Cogn Affect Neurosci 2017[Apr]; 12 (4): 651-61 PMID28119505show ga Pleasurable stimuli, including reward, inhibit pain, but the level of the neuraxis at which they do so and the cerebral processes involved are unknown. Here, we characterized a brain circuitry mediating pain inhibition by reward. Twenty-four healthy participants underwent functional magnetic resonance imaging while playing a wheel of fortune game with simultaneous thermal pain stimuli and monetary wins or losses. As expected, winning decreased pain perception compared to losing. Inter-individual differences in pain modulation by monetary wins relative to losses correlated with activation in the medial orbitofrontal cortex (mOFC). When pain and reward occured simultaneously, mOFCs functional connectivity changed: the signal time course in the mOFC condition-dependent correlated negatively with the signal time courses in the rostral anterior insula, anterior-dorsal cingulate cortex and primary somatosensory cortex, which might signify moment-to-moment down-regulation of these regions by the mOFC. Monetary wins and losses did not change the magnitude of pain-related activation, including in regions that code perceived pain intensity when nociceptive input varies and/or receive direct nociceptive input. Pain inhibition by reward appears to involve brain regions not typically involved in nociceptive intensity coding but likely mediate changes in the significance and/or value of pain. äOrbitofrontal cortex mediates pain inhibition by monetary reward (epmc).pdf DeepDyve Pubget Overpricing