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2017 ; 8
(ä): 54-62
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Clostridium difficile bacteremia: Report of two cases in French hospitals and
comprehensive review of the literature
#MMPMID28417069
Doufair M
; Eckert C
; Drieux L
; Amani-Moibeni C
; Bodin L
; Denis M
; Grange JD
; Arlet G
; Barbut F
IDCases
2017[]; 8
(ä): 54-62
PMID28417069
show ga
We report two cases of bacteremia due to Clostridium difficile from two French
hospitals. The first patient with previously diagnosed rectal carcinoma underwent
courses of chemotherapy, and antimicrobial treatment, and survived the C.
difficile bacteremia. The second patient with colon perforation and newly
diagnosed lung cancer underwent antimicrobial treatment in an ICU but died
shortly after the episode of C. difficile bacteremia. A review of the literature
allowed the identification of 137 cases of bacteremia between July 1962 and
November 2016. Advanced age, gastro-intestinal disruption, severe underlying
diseases and antimicrobial exposure were the major risk factors for C. difficile
bacteremia. Antimicrobial therapy was primarily based on metronidazole and/or
vancomycin. The crude mortality rate was 35% (21/60).