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10.1186/s12911-017-0429-1

http://scihub22266oqcxt.onion/10.1186/s12911-017-0429-1
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suck abstract from ncbi


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pmid28407816      BMC+Med+Inform+Decis+Mak 2017 ; 17 (ä): ä
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  • Automatic identification of variables in epidemiological datasets using logic regression #MMPMID28407816
  • Lorenz MW; Abdi NA; Scheckenbach F; Pflug A; Bülbül A; Catapano AL; Agewall S; Ezhov M; Bots ML; Kiechl S; Orth A
  • BMC Med Inform Decis Mak 2017[]; 17 (ä): ä PMID28407816show ga
  • Background: For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error-prone task. Automated or semi-automated identification of variables can help to reduce the workload and improve the data quality. For semi-automation high sensitivity in the recognition of matching variables is particularly important, because it allows creating software which for a target variable presents a choice of source variables, from which a user can choose the matching one, with only low risk of having missed a correct source variable. Methods: For each variable in a set of target variables, a number of simple rules were manually created. With logic regression, an optimal Boolean combination of these rules was searched for every target variable, using a random subset of a large database of epidemiological and clinical cohort data (construction subset). In a second subset of this database (validation subset), this optimal combination rules were validated. Results: In the construction sample, 41 target variables were allocated on average with a positive predictive value (PPV) of 34%, and a negative predictive value (NPV) of 95%. In the validation sample, PPV was 33%, whereas NPV remained at 94%. In the construction sample, PPV was 50% or less in 63% of all variables, in the validation sample in 71% of all variables. Conclusions: We demonstrated that the application of logic regression in a complex data management task in large epidemiological IPD meta-analyses is feasible. However, the performance of the algorithm is poor, which may require backup strategies. Electronic supplementary material: The online version of this article (doi:10.1186/s12911-017-0429-1) contains supplementary material, which is available to authorized users.
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