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10.1007/s12035-015-9681-5 http://scihub22266oqcxt.onion/10.1007/s12035-015-9681-5 C5390001!5390001 !27032388     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27032388 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine |pdf=|usr=}}{{27032388 }} gab.com Text Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine JO: Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=27032388 #FOAvip Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the ?(1A) subunit of voltage-gated Ca(V)2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation ('FHM1 R192Q mice') exhibit an increased susceptibility to cortical spreading depression (CSD), the mechanism underlying migraine aura. Here, we analysed gene expression profiles from isolated cortical tissue of FHM1 R192Q mice 24 h after experimentally induced CSD in order to identify molecular pathways affected by CSD. Gene expression profiles were generated using deep serial analysis of gene expression sequencing. Our data reveal a signature of inflammatory signalling upon CSD in the cortex of both mutant and wild-type mice. However, only in the brains of FHM1 R192Q mice specific genes are up-regulated in response to CSD that are implicated in interferon-related inflammatory signalling. Our findings show that CSD modulates inflammatory processes in both wild-type and mutant brains, but that an additional unique inflammatory signature becomes expressed after CSD in a relevant mouse model of migraine. Twit Text FOAVip Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine ????Mol Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=27032388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27032388 #FOAvip English Wikipedia <ref>{{Cite pmid|27032388 }}</ref> Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine #MMPMID27032388 Eising E ; Shyti R ; 't Hoen PAC ; Vijfhuizen LS ; Huisman SMH ; Broos LAM ; Mahfouz A ; Reinders MJT ; Ferrari MD ; Tolner EA ; de Vries B ; van den Maagdenberg AMJM Mol Neurobiol 2017[May]; 54 (4 ): 2986-2996 PMID27032388 show ga Familial hemiplegic migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in CACNA1A that encodes the ?(1A) subunit of voltage-gated Ca(V)2.1 calcium channels. Transgenic knock-in mice that carry the human FHM1 R192Q missense mutation ('FHM1 R192Q mice') exhibit an increased susceptibility to cortical spreading depression (CSD), the mechanism underlying migraine aura. Here, we analysed gene expression profiles from isolated cortical tissue of FHM1 R192Q mice 24 h after experimentally induced CSD in order to identify molecular pathways affected by CSD. Gene expression profiles were generated using deep serial analysis of gene expression sequencing. Our data reveal a signature of inflammatory signalling upon CSD in the cortex of both mutant and wild-type mice. However, only in the brains of FHM1 R192Q mice specific genes are up-regulated in response to CSD that are implicated in interferon-related inflammatory signalling. Our findings show that CSD modulates inflammatory processes in both wild-type and mutant brains, but that an additional unique inflammatory signature becomes expressed after CSD in a relevant mouse model of migraine. |Animals [MESH] |Binding Sites [MESH] |Cerebral Cortex/pathology/physiopathology [MESH] |Cluster Analysis [MESH] |Cortical Spreading Depression/*genetics [MESH] |Disease Models, Animal [MESH] |Epistasis, Genetic [MESH] |Gene Ontology [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Inflammation/*complications/*pathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Migraine Disorders/*complications/genetics/*physiopathology [MESH] |Protein Interaction Maps/genetics [MESH] |Transcription Factors/metabolism [MESH]Cortical Spreading Depression Causes Unique Dysregulation of Inflammat(epmc).pdf DeepDyve Pubget Overpricing