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10.1186/s40169-017-0145-6 http://scihub22266oqcxt.onion/10.1186/s40169-017-0145-6 C5389955!5389955!28405930     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Med 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28405930|t=2017. Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis |pdf=|usr=}}{{28405930}} gab.com Text Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis JO: Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28405930 #FOAvip Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-the-art DNA- and RNA-sequencing methods now provide high-resolution genomic and gene expression portraits of individual cells, facilitating the study of complex molecular heterogeneity in cancer. Important developments in single-cell sequencing (SCS) technologies over the past 5 years provide numerous advantages over traditional sequencing methods for understanding the complexity of carcinogenesis, but significant hurdles must be overcome before SCS can be clinically useful. In this review, we: (1) highlight current methodologies and recent technological advances for isolating single cells, single-cell whole-genome and whole-transcriptome amplification using minute amounts of nucleic acids, and SCS, (2) summarize research investigating molecular heterogeneity at the genomic and transcriptomic levels and how this heterogeneity affects clonal evolution and metastasis, and (3) discuss the promise for integrating SCS in the clinical care arena for improved patient care. Twit Text FOAVip Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis ????Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28405930 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405930 #FOAvip English Wikipedia <ref>{{Cite pmid|28405930}}</ref> Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis #MMPMID28405930 Ellsworth DL; Blackburn HL; Shriver CD; Rabizadeh S; Soon-Shiong P; Ellsworth RE Clin Transl Med 2017[]; 6 (ä): ä PMID28405930show ga Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-the-art DNA- and RNA-sequencing methods now provide high-resolution genomic and gene expression portraits of individual cells, facilitating the study of complex molecular heterogeneity in cancer. Important developments in single-cell sequencing (SCS) technologies over the past 5 years provide numerous advantages over traditional sequencing methods for understanding the complexity of carcinogenesis, but significant hurdles must be overcome before SCS can be clinically useful. In this review, we: (1) highlight current methodologies and recent technological advances for isolating single cells, single-cell whole-genome and whole-transcriptome amplification using minute amounts of nucleic acids, and SCS, (2) summarize research investigating molecular heterogeneity at the genomic and transcriptomic levels and how this heterogeneity affects clonal evolution and metastasis, and (3) discuss the promise for integrating SCS in the clinical care arena for improved patient care. äSingle-cell sequencing and tumorigenesis: improved understanding of tu(epmc).pdf DeepDyve Pubget Overpricing