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10.1093/nar/gkw872 http://scihub22266oqcxt.onion/10.1093/nar/gkw872 C5389717!5389717!28204614     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28204614&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (4): 2081-98 Nephropedia Template TP {{tp|p=28204614|t=2017. A continuum of mRNP complexes in embryonic microRNA-mediated silencing |pdf=|usr=}}{{28204614}} gab.com Text A continuum of mRNP complexes in embryonic microRNA-mediated silencing JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28204614 #FOAvip MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and play key roles in development, homeostasis and disease. The gene regulation mechanisms they instigate are largely mediated through the CCR4?NOT deadenylase complex, but the molecular events that occur on target mRNAs are poorly resolved. We observed a broad convergence of interactions of germ granule and P body mRNP components on AIN-1/GW182 and NTL-1/CNOT1 in Caenorhabditis elegans embryos. We show that the miRISC progressively matures on the target mRNA from a scanning form into an effector mRNP particle by sequentially recruiting the CCR4?NOT complex, decapping and decay, or germ granule proteins. Finally, we implicate intrinsically disordered proteins, key components in mRNP architectures, in the embryonic function of lsy-6 miRNA. Our findings define dynamic steps of effector mRNP assembly in miRNA-mediated silencing, and identify a functional continuum between germ granules and P bodies in the C. elegans embryo. Twit Text FOAVip A continuum of mRNP complexes in embryonic microRNA-mediated silencing ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28204614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28204614 #FOAvip English Wikipedia <ref>{{Cite pmid|28204614}}</ref> A continuum of mRNP complexes in embryonic microRNA-mediated silencing #MMPMID28204614 Wu E; Vashisht AA; Chapat C; Flamand MN; Cohen E; Sarov M; Tabach Y; Sonenberg N; Wohlschlegel J; Duchaine TF Nucleic Acids Res 2017[Feb]; 45 (4): 2081-98 PMID28204614show ga MicroRNAs (miRNAs) impinge on the translation and stability of their target mRNAs, and play key roles in development, homeostasis and disease. The gene regulation mechanisms they instigate are largely mediated through the CCR4?NOT deadenylase complex, but the molecular events that occur on target mRNAs are poorly resolved. We observed a broad convergence of interactions of germ granule and P body mRNP components on AIN-1/GW182 and NTL-1/CNOT1 in Caenorhabditis elegans embryos. We show that the miRISC progressively matures on the target mRNA from a scanning form into an effector mRNP particle by sequentially recruiting the CCR4?NOT complex, decapping and decay, or germ granule proteins. Finally, we implicate intrinsically disordered proteins, key components in mRNP architectures, in the embryonic function of lsy-6 miRNA. Our findings define dynamic steps of effector mRNP assembly in miRNA-mediated silencing, and identify a functional continuum between germ granules and P bodies in the C. elegans embryo. äA continuum of mRNP complexes in embryonic microRNA-mediated silencing(epmc).pdf DeepDyve Pubget Overpricing