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10.1093/nar/gkx001 http://scihub22266oqcxt.onion/10.1093/nar/gkx001 C5389686!5389686!28100701     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (6): 3231-41 Nephropedia Template TP {{tp|p=28100701|t=2017. Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage |pdf=|usr=}}{{28100701}} gab.com Text Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28100701 #FOAvip Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidine deaminases can initiate catabolism of cytoplasmic mitochondrial DNA. Using the human myeloid cell line THP-1 with an interferon inducible APOBEC3A gene, we show that cytoplasmic DNA triggers interferon ? and ? production through the RNA polymerase III transcription/RIG-I pathway leading to massive upregulation of APOBEC3A. By catalyzing C?U editing in single stranded DNA fragments, the enzyme prevents them from re-annealing so attenuating the danger signal. The price to pay is chromosomal DNA damage in the form of CG?TA mutations and double stranded DNA breaks which, in the context of chronic inflammation, could drive cells down the path toward cancer. Twit Text FOAVip Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28100701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28100701 #FOAvip English Wikipedia <ref>{{Cite pmid|28100701}}</ref> Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage #MMPMID28100701 Suspène R; Mussil B; Laude H; Caval V; Berry N; Bouzidi MS; Thiers V; Wain-Hobson S; Vartanian JP Nucleic Acids Res 2017[Apr]; 45 (6): 3231-41 PMID28100701show ga Foreign and self-cytoplasmic DNA are recognized by numerous DNA sensor molecules leading to the production of type I interferons. Such DNA agonists should be degraded otherwise cells would be chronically stressed. Most human APOBEC3 cytidine deaminases can initiate catabolism of cytoplasmic mitochondrial DNA. Using the human myeloid cell line THP-1 with an interferon inducible APOBEC3A gene, we show that cytoplasmic DNA triggers interferon ? and ? production through the RNA polymerase III transcription/RIG-I pathway leading to massive upregulation of APOBEC3A. By catalyzing C?U editing in single stranded DNA fragments, the enzyme prevents them from re-annealing so attenuating the danger signal. The price to pay is chromosomal DNA damage in the form of CG?TA mutations and double stranded DNA breaks which, in the context of chronic inflammation, could drive cells down the path toward cancer. äSelf-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading t(epmc).pdf DeepDyve Pubget Overpricing