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10.1093/nar/gkw1258 http://scihub22266oqcxt.onion/10.1093/nar/gkw1258 C5389556!5389556 !27956497     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27956497 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (6 ): 3102-3115 Nephropedia Template TP {{tp|p=27956497 |t=2017. Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts |pdf=|usr=}}{{27956497 }} gab.com Text Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27956497 #FOAvip The dynamic interaction of DNA methylation and transcription factor binding in regulating spatiotemporal gene expression is essential for embryogenesis, but the underlying mechanisms remain understudied. In this study, using mouse models and integration of in vitro and in vivo genetic and epigenetic analyses, we show that the binding of REST (repressor element 1 (RE1) silencing transcription factor; also known as NRSF) to its cognate RE1 sequences is temporally regulated by non-CpG methylation. This process is dependent on DNA methyltransferase 3B (DNMT3B) and leads to suppression of adult cardiac genes in developing hearts. We demonstrate that DNMT3B preferentially mediates non-CpG methylation of REST-targeted genes in the developing heart. Downregulation of DNMT3B results in decreased non-CpG methylation of RE1 sequences, reduced REST occupancy, and consequently release of the transcription suppression during later cardiac development. Together, these findings reveal a critical gene silencing mechanism in developing mammalian hearts that is regulated by the dynamic interaction of DNMT3B-mediated non-CpG methylation and REST binding. Twit Text FOAVip Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27956497 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27956497 #FOAvip English Wikipedia <ref>{{Cite pmid|27956497 }}</ref> Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts #MMPMID27956497 Zhang D ; Wu B ; Wang P ; Wang Y ; Lu P ; Nechiporuk T ; Floss T ; Greally JM ; Zheng D ; Zhou B Nucleic Acids Res 2017[Apr]; 45 (6 ): 3102-3115 PMID27956497 show ga The dynamic interaction of DNA methylation and transcription factor binding in regulating spatiotemporal gene expression is essential for embryogenesis, but the underlying mechanisms remain understudied. In this study, using mouse models and integration of in vitro and in vivo genetic and epigenetic analyses, we show that the binding of REST (repressor element 1 (RE1) silencing transcription factor; also known as NRSF) to its cognate RE1 sequences is temporally regulated by non-CpG methylation. This process is dependent on DNA methyltransferase 3B (DNMT3B) and leads to suppression of adult cardiac genes in developing hearts. We demonstrate that DNMT3B preferentially mediates non-CpG methylation of REST-targeted genes in the developing heart. Downregulation of DNMT3B results in decreased non-CpG methylation of RE1 sequences, reduced REST occupancy, and consequently release of the transcription suppression during later cardiac development. Together, these findings reveal a critical gene silencing mechanism in developing mammalian hearts that is regulated by the dynamic interaction of DNMT3B-mediated non-CpG methylation and REST binding. |*Gene Expression Regulation, Developmental [MESH] |*Gene Silencing [MESH] |Animals [MESH] |Binding Sites [MESH] |Cells, Cultured [MESH] |CpG Islands [MESH] |DNA (Cytosine-5-)-Methyltransferases/genetics/*metabolism/physiology [MESH] |DNA Methylation [MESH] |DNA Methyltransferase 3B [MESH] |Heart/*embryology [MESH] |Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/biosynthesis/genetics [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myocardium/*metabolism [MESH] |Potassium Channels/biosynthesis/genetics [MESH] |Protein Binding [MESH]Non-CpG methylation by DNMT3B facilitates REST binding and gene silenc(epmc).pdf DeepDyve Pubget Overpricing