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10.1093/nar/gkx071 http://scihub22266oqcxt.onion/10.1093/nar/gkx071 C5389554!5389554!28168305     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (6): 3280-96 Nephropedia Template TP {{tp|p=28168305|t=2017. CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6 |pdf=|usr=}}{{28168305}} gab.com Text CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6 JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28168305 #FOAvip The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced cnbp expression through an NF-?B-dependent manner and a positive autoregulatory mechanism, which enables prolonged il-6 gene expression. This event depends strictly on LPS-induced CNBP nuclear translocation through phosphorylation-mediated dimerization. Consequently, cnbp-depleted zebrafish are highly susceptible to Shigella flexneri infection in vivo. Collectively, these observations identify CNBP as a key transcriptional regulator required for activating and maintaining the immune response. Twit Text FOAVip CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6 ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28168305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28168305 #FOAvip English Wikipedia <ref>{{Cite pmid|28168305}}</ref> CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6 #MMPMID28168305 Lee E; Lee TA; Kim JH; Park A; Ra EA; Kang S; Choi Hj; Choi JL; Huh HD; Lee JE; Lee S; Park B Nucleic Acids Res 2017[Apr]; 45 (6): 3280-96 PMID28168305show ga The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts as a transcription regulator that is required for activating the innate immune response. We identified specific CNBP-binding motifs present in the promoter region of sustained inflammatory cytokines, thus, directly inducing the expression of target genes. In particular, lipopolysaccharide (LPS) induced cnbp expression through an NF-?B-dependent manner and a positive autoregulatory mechanism, which enables prolonged il-6 gene expression. This event depends strictly on LPS-induced CNBP nuclear translocation through phosphorylation-mediated dimerization. Consequently, cnbp-depleted zebrafish are highly susceptible to Shigella flexneri infection in vivo. Collectively, these observations identify CNBP as a key transcriptional regulator required for activating and maintaining the immune response. äCNBP acts as a key transcriptional regulator of sustained expression o(epmc).pdf DeepDyve Pubget Overpricing