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suck abstract from ncbi


10.1093/nar/gkw1185

http://scihub22266oqcxt.onion/10.1093/nar/gkw1185
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C5389546!5389546!27903911
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suck abstract from ncbi


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pmid27903911      Nucleic+Acids+Res 2017 ; 45 (6): e42
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  • miRTar2GO: a novel rule-based model learning method for cell line specific microRNA target prediction that integrates Ago2 CLIP-Seq and validated microRNA?target interaction data #MMPMID27903911
  • Ahadi A; Sablok G; Hutvagner G
  • Nucleic Acids Res 2017[Apr]; 45 (6): e42 PMID27903911show ga
  • MicroRNAs (miRNAs) are ?19?22 nucleotides (nt) long regulatory RNAs that regulate gene expression by recognizing and binding to complementary sequences on mRNAs. The key step in revealing the function of a miRNA, is the identification of miRNA target genes. Recent biochemical advances including PAR-CLIP and HITS-CLIP allow for improved miRNA target predictions and are widely used to validate miRNA targets. Here, we present miRTar2GO, which is a model, trained on the common rules of miRNA?target interactions, Argonaute (Ago) CLIP-Seq data and experimentally validated miRNA target interactions. miRTar2GO is designed to predict miRNA target sites using more relaxed miRNA?target binding characteristics. More importantly, miRTar2GO allows for the prediction of cell-type specific miRNA targets. We have evaluated miRTar2GO against other widely used miRNA target prediction algorithms and demonstrated that miRTar2GO produced significantly higher F1 and G scores. Target predictions, binding specifications, results of the pathway analysis and gene ontology enrichment of miRNA targets are freely available at http://www.mirtar2go.org.
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