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10.1093/nar/gkx053 http://scihub22266oqcxt.onion/10.1093/nar/gkx053 C5389538!5389538!28426094     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (5): 2675-86 Nephropedia Template TP {{tp|p=28426094|t=2017. SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription |pdf=|usr=}}{{28426094}} gab.com Text SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28426094 #FOAvip SIRT7 is an NAD+-dependent protein deacetylase that regulates cell growth and proliferation. Previous studies have shown that SIRT7 is required for RNA polymerase I (Pol I) transcription and pre-rRNA processing. Here, we took a proteomic approach to identify novel molecular targets and characterize the role of SIRT7 in non-nucleolar processes. We show that SIRT7 interacts with numerous proteins involved in transcriptional regulation and RNA metabolism, the majority of interactions requiring ongoing transcription. In addition to its role in Pol I transcription, we found that SIRT7 also regulates transcription of snoRNAs and mRNAs. Mechanistically, SIRT7 promotes the release of P-TEFb from the inactive 7SK snRNP complex and deacetylates CDK9, a subunit of the elongation factor P-TEFb, which activates transcription by phosphorylating serine 2 within the C-terminal domain (CTD) of Pol II. SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation. Twit Text FOAVip SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28426094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28426094 #FOAvip English Wikipedia <ref>{{Cite pmid|28426094}}</ref> SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription #MMPMID28426094 Blank MF; Chen S; Poetz F; Schnölzer M; Voit R; Grummt I Nucleic Acids Res 2017[Mar]; 45 (5): 2675-86 PMID28426094show ga SIRT7 is an NAD+-dependent protein deacetylase that regulates cell growth and proliferation. Previous studies have shown that SIRT7 is required for RNA polymerase I (Pol I) transcription and pre-rRNA processing. Here, we took a proteomic approach to identify novel molecular targets and characterize the role of SIRT7 in non-nucleolar processes. We show that SIRT7 interacts with numerous proteins involved in transcriptional regulation and RNA metabolism, the majority of interactions requiring ongoing transcription. In addition to its role in Pol I transcription, we found that SIRT7 also regulates transcription of snoRNAs and mRNAs. Mechanistically, SIRT7 promotes the release of P-TEFb from the inactive 7SK snRNP complex and deacetylates CDK9, a subunit of the elongation factor P-TEFb, which activates transcription by phosphorylating serine 2 within the C-terminal domain (CTD) of Pol II. SIRT7 counteracts GCN5-directed acetylation of lysine 48 within the catalytic domain of CDK9, deacetylation promoting CTD phosphorylation and transcription elongation. äSIRT7-dependent deacetylation of CDK9 activates RNA polymerase II tran(epmc).pdf DeepDyve Pubget Overpricing