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10.1093/nar/gkw1240 http://scihub22266oqcxt.onion/10.1093/nar/gkw1240 C5389534!5389534!27940560     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (6): 3059-67 Nephropedia Template TP {{tp|p=27940560|t=2017. Nucleosome-free DNA regions differentially affect distant communication in chromatin |pdf=|usr=}}{{27940560}} gab.com Text Nucleosome-free DNA regions differentially affect distant communication in chromatin JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27940560 #FOAvip Communication between distantly spaced genomic regions is one of the key features of gene regulation in eukaryotes. Chromatin per se can stimulate efficient enhancer-promoter communication (EPC); however, the role of chromatin structure and dynamics in this process remains poorly understood. Here we show that nucleosome spacing and the presence of nucleosome-free DNA regions can modulate chromatin structure/dynamics and, in turn, affect the rate of EPC in vitro and in silico. Increasing the length of internucleosomal linker DNA from 25 to 60 bp results in more efficient EPC. The presence of longer nucleosome-free DNA regions can positively or negatively affect the rate of EPC, depending upon the length and location of the DNA region within the chromatin fiber. Thus the presence of histone-free DNA regions can differentially affect the efficiency of EPC, suggesting that gene regulation over a distance could be modulated by changes in the length of internucleosomal DNA spacers. Twit Text FOAVip Nucleosome-free DNA regions differentially affect distant communication in chromatin ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27940560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27940560 #FOAvip English Wikipedia <ref>{{Cite pmid|27940560}}</ref> Nucleosome-free DNA regions differentially affect distant communication in chromatin #MMPMID27940560 Nizovtseva EV; Clauvelin N; Todolli S; Polikanov YS; Kulaeva OI; Wengrzynek S; Olson WK; Studitsky VM Nucleic Acids Res 2017[Apr]; 45 (6): 3059-67 PMID27940560show ga Communication between distantly spaced genomic regions is one of the key features of gene regulation in eukaryotes. Chromatin per se can stimulate efficient enhancer-promoter communication (EPC); however, the role of chromatin structure and dynamics in this process remains poorly understood. Here we show that nucleosome spacing and the presence of nucleosome-free DNA regions can modulate chromatin structure/dynamics and, in turn, affect the rate of EPC in vitro and in silico. Increasing the length of internucleosomal linker DNA from 25 to 60 bp results in more efficient EPC. The presence of longer nucleosome-free DNA regions can positively or negatively affect the rate of EPC, depending upon the length and location of the DNA region within the chromatin fiber. Thus the presence of histone-free DNA regions can differentially affect the efficiency of EPC, suggesting that gene regulation over a distance could be modulated by changes in the length of internucleosomal DNA spacers. äNucleosome-free DNA regions differentially affect distant communicatio(epmc).pdf DeepDyve Pubget Overpricing