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10.1016/j.jmb.2017.02.017 http://scihub22266oqcxt.onion/10.1016/j.jmb.2017.02.017 C5389416!5389416!28249778     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2017 ; 429 (7): 999-1008 Nephropedia Template TP {{tp|p=28249778|t=2017. DNA and I?B? both induce long range conformational changes in NF?B |pdf=|usr=}}{{28249778}} gab.com Text DNA and I B both induce long range conformational changes in NF B JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28249778 #FOAvip We recently discovered that I?B? enhances the rate of release of NF?B from DNA target sites in a process we have termed molecular stripping. Coarse-grained molecular dynamics simulations of the stripping pathway revealed two mechanisms for the enhanced release rate; the negatively charged PEST region of I?B? electrostatically repels the DNA, and binding of I?B? appears to twist the NF?B heterodimer so that DNA can no longer bind. Here we report amide hydrogen/deuterium exchange data that reveals long-range allosteric changes in the NF?B (RelA-p50) heterodimer induced by DNA or I?B? binding. The data suggest that the two immunoglobulin-like subdomains of each Rel-homology region, which are connected by a flexible linker in the heterodimer, communicate in such a way that when DNA binds to the N-terminal DNA binding domains, the nuclear localization signal becomes more highly exchanging. Conversely, when I?B? binds to the dimerization domains, amide exchange throughout the DNA binding domains is decreased as if the entire domain is becoming globally stabilized. The results help understand how the subtle mechanism of molecular stripping actually occurs. Twit Text FOAVip DNA and I B both induce long range conformational changes in NF B ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28249778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28249778 #FOAvip English Wikipedia <ref>{{Cite pmid|28249778}}</ref> DNA and I?B? both induce long range conformational changes in NF?B #MMPMID28249778 Ramsey KM; Dembinski HE; Chen W; Ricci CG; Komives EA J Mol Biol 2017[Apr]; 429 (7): 999-1008 PMID28249778show ga We recently discovered that I?B? enhances the rate of release of NF?B from DNA target sites in a process we have termed molecular stripping. Coarse-grained molecular dynamics simulations of the stripping pathway revealed two mechanisms for the enhanced release rate; the negatively charged PEST region of I?B? electrostatically repels the DNA, and binding of I?B? appears to twist the NF?B heterodimer so that DNA can no longer bind. Here we report amide hydrogen/deuterium exchange data that reveals long-range allosteric changes in the NF?B (RelA-p50) heterodimer induced by DNA or I?B? binding. The data suggest that the two immunoglobulin-like subdomains of each Rel-homology region, which are connected by a flexible linker in the heterodimer, communicate in such a way that when DNA binds to the N-terminal DNA binding domains, the nuclear localization signal becomes more highly exchanging. Conversely, when I?B? binds to the dimerization domains, amide exchange throughout the DNA binding domains is decreased as if the entire domain is becoming globally stabilized. The results help understand how the subtle mechanism of molecular stripping actually occurs. äDNA and I?B? both induce long range conformational changes in NF?B (epmc).pdf DeepDyve Pubget Overpricing