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10.1073/pnas.1611428114 http://scihub22266oqcxt.onion/10.1073/pnas.1611428114 C5389321!5389321!28320972     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (14): E2975-82 Nephropedia Template TP {{tp|p=28320972|t=2017. Sensing relative signal in the Tgf-?/Smad pathway |pdf=|usr=}}{{28320972}} gab.com Text Sensing relative signal in the Tgf- /Smad pathway JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28320972 #FOAvip It is not fully understood how cells process information in the face of noise. We posed this question in the transforming growth factor-? (Tgf-?) pathway, a major intercellular signaling pathway in animal cells. We found evidence that rather than sensing the signaling state of the Tgf-? pathway, cells sense the signaling state relative to background. Finding that signaling dynamics are interpreted in a relative manner may have implications for how we understand the pathway?s context-dependent outcomes and roles in diseases. Our work reinforces an emerging principle that individual cells process signal in a relative manner. Twit Text FOAVip Sensing relative signal in the Tgf- /Smad pathway ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28320972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28320972 #FOAvip English Wikipedia <ref>{{Cite pmid|28320972}}</ref> Sensing relative signal in the Tgf-?/Smad pathway #MMPMID28320972 Frick CL; Yarka C; Nunns H; Goentoro L Proc Natl Acad Sci U S A 2017[Apr]; 114 (14): E2975-82 PMID28320972show ga It is not fully understood how cells process information in the face of noise. We posed this question in the transforming growth factor-? (Tgf-?) pathway, a major intercellular signaling pathway in animal cells. We found evidence that rather than sensing the signaling state of the Tgf-? pathway, cells sense the signaling state relative to background. Finding that signaling dynamics are interpreted in a relative manner may have implications for how we understand the pathway?s context-dependent outcomes and roles in diseases. Our work reinforces an emerging principle that individual cells process signal in a relative manner. äSensing relative signal in the Tgf-?/Smad pathway (epmc).pdf DeepDyve Pubget Overpricing