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10.1073/pnas.1618291114 http://scihub22266oqcxt.onion/10.1073/pnas.1618291114 C5389309!5389309!28330995     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (14): E2862-71 Nephropedia Template TP {{tp|p=28330995|t=2017. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury |pdf=|usr=}}{{28330995}} gab.com Text Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28330995 #FOAvip Neonatal crystallizable fragment receptor (FcRn) regulates immunity and homeostasis of the two most abundant circulating proteins, IgG and albumin. FcRn is expressed in hepatocytes, but hepatic FcRn function is unknown. We show that hepatic FcRn regulates albumin biodistribution. Absence of FcRn in the liver leads to hypoalbuminemia by preventing efficient albumin delivery into the circulation, causing albumin retention within hepatocytes and increasing biliary albumin excretion. Blockade of albumin?FcRn interactions protects liver from damage induced by acetaminophen, a hepatotoxin. This protection results from hepatocyte accumulation of albumin, which scavenges superoxide radicals, and from the redirection of albumin-bound acetaminophen into the bile. Therefore, FcRn-mediated homeostatic distribution of albumin into the bloodstream renders hepatocytes susceptible to acute hepatotoxin exposure, and inhibition of FcRn in the hepatocyte is protective. Twit Text FOAVip Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28330995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28330995 #FOAvip English Wikipedia <ref>{{Cite pmid|28330995}}</ref> Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury #MMPMID28330995 Pyzik M; Rath T; Kuo TT; Win S; Baker K; Hubbard JJ; Grenha R; Gandhi A; Krämer TD; Mezo AR; Taylor ZS; McDonnell K; Nienaber V; Andersen JT; Mizoguchi A; Blumberg L; Purohit S; Jones SD; Christianson G; Lencer WI; Sandlie I; Kaplowitz N; Roopenian DC; Blumberg RS Proc Natl Acad Sci U S A 2017[Apr]; 114 (14): E2862-71 PMID28330995show ga Neonatal crystallizable fragment receptor (FcRn) regulates immunity and homeostasis of the two most abundant circulating proteins, IgG and albumin. FcRn is expressed in hepatocytes, but hepatic FcRn function is unknown. We show that hepatic FcRn regulates albumin biodistribution. Absence of FcRn in the liver leads to hypoalbuminemia by preventing efficient albumin delivery into the circulation, causing albumin retention within hepatocytes and increasing biliary albumin excretion. Blockade of albumin?FcRn interactions protects liver from damage induced by acetaminophen, a hepatotoxin. This protection results from hepatocyte accumulation of albumin, which scavenges superoxide radicals, and from the redirection of albumin-bound acetaminophen into the bile. Therefore, FcRn-mediated homeostatic distribution of albumin into the bloodstream renders hepatocytes susceptible to acute hepatotoxin exposure, and inhibition of FcRn in the hepatocyte is protective. äHepatic FcRn regulates albumin homeostasis and susceptibility to liver(epmc).pdf DeepDyve Pubget Overpricing