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10.1038/srep08078 http://scihub22266oqcxt.onion/10.1038/srep08078 C5389036!5389036!25627963     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=25627963|t=2015. Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity |pdf=|usr=}}{{25627963}} gab.com Text Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25627963 #FOAvip Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 in HEK293 cells and employed an iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism of ASK1 in OTA-induced renal cytotoxicity. Our results showed that ASK1 knockdown alleviated OTA-induced ROS generation and ??m loss and thus desensitized the cells to OTA-induced apoptosis. We identified 33 and 24 differentially expressed proteins upon OTA treatment in scrambled and ASK1 knockdown cells, respectively. Pathway classification and analysis revealed that ASK1 participated in OTA-induced inhibition of mRNA splicing, nucleotide metabolism, the cell cycle, DNA repair, and the activation of lipid metabolism. We concluded that ASK1 plays an essential role in promoting OTA-induced renal cytotoxicity. Twit Text FOAVip Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25627963 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25627963 #FOAvip English Wikipedia <ref>{{Cite pmid|25627963}}</ref> Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity #MMPMID25627963 Liang R; Shen XL; Zhang B; Li Y; Xu W; Zhao C; Luo Y; Huang K Sci Rep 2015[]; 5 (ä): ä PMID25627963show ga Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this study, we performed RNA interference of ASK1 in HEK293 cells and employed an iTRAQ-based quantitative proteomics approach to globally investigate the regulatory mechanism of ASK1 in OTA-induced renal cytotoxicity. Our results showed that ASK1 knockdown alleviated OTA-induced ROS generation and ??m loss and thus desensitized the cells to OTA-induced apoptosis. We identified 33 and 24 differentially expressed proteins upon OTA treatment in scrambled and ASK1 knockdown cells, respectively. Pathway classification and analysis revealed that ASK1 participated in OTA-induced inhibition of mRNA splicing, nucleotide metabolism, the cell cycle, DNA repair, and the activation of lipid metabolism. We concluded that ASK1 plays an essential role in promoting OTA-induced renal cytotoxicity. äApoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced ren(epmc).pdf DeepDyve Pubget Overpricing