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10.1093/nar/gkw979 http://scihub22266oqcxt.onion/10.1093/nar/gkw979 C5388433!5388433 !28180290     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28180290 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (3 ): 1114-1129 Nephropedia Template TP {{tp|p=28180290 |t=2017. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1 |pdf=|usr=}}{{28180290 }} gab.com Text KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1 JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180290 #FOAvip Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals. The multivalent engagement with DNA and HP1 results in a nucleosome binding circuit in which KDM2A can be recruited to H3K9me3-modified chromatin through HP1, and HP1 can be recruited to unmodified chromatin by KDM2A. A KDM2A mutant deficient in HP1-binding is inactive in an in vivo overexpression assay in zebrafish embryos demonstrating that the HP1 interaction is essential for KDM2A function. Our results reveal a complex regulation of chromatin binding for both KDM2A and HP1 that is modulated by DNA- and H3K9-methylation, and suggest a direct role for KDM2A in chromatin silencing. Twit Text FOAVip KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1 ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180290 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28180290 #FOAvip English Wikipedia <ref>{{Cite pmid|28180290 }}</ref> KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1 #MMPMID28180290 Borgel J ; Tyl M ; Schiller K ; Pusztai Z ; Dooley CM ; Deng W ; Wooding C ; White RJ ; Warnecke T ; Leonhardt H ; Busch-Nentwich EM ; Bartke T Nucleic Acids Res 2017[Feb]; 45 (3 ): 1114-1129 PMID28180290 show ga Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1. This nucleosome interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals. The multivalent engagement with DNA and HP1 results in a nucleosome binding circuit in which KDM2A can be recruited to H3K9me3-modified chromatin through HP1, and HP1 can be recruited to unmodified chromatin by KDM2A. A KDM2A mutant deficient in HP1-binding is inactive in an in vivo overexpression assay in zebrafish embryos demonstrating that the HP1 interaction is essential for KDM2A function. Our results reveal a complex regulation of chromatin binding for both KDM2A and HP1 that is modulated by DNA- and H3K9-methylation, and suggest a direct role for KDM2A in chromatin silencing. |Animals [MESH] |Animals, Genetically Modified [MESH] |Cell Line [MESH] |Chromobox Protein Homolog 5 [MESH] |Chromosomal Proteins, Non-Histone/*chemistry/genetics/*metabolism [MESH] |CpG Islands [MESH] |Cricetinae [MESH] |DNA Methylation [MESH] |F-Box Proteins/*chemistry/genetics/*metabolism [MESH] |HEK293 Cells [MESH] |HeLa Cells [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Jumonji Domain-Containing Histone Demethylases/*chemistry/genetics/*metabolism [MESH] |Models, Genetic [MESH] |Mutation [MESH] |Neoplasms/genetics/metabolism [MESH] |Nucleosomes/genetics/metabolism [MESH] |Protein Interaction Domains and Motifs [MESH] |Recombinant Fusion Proteins/chemistry/genetics/metabolism [MESH] |Two-Hybrid System Techniques [MESH] |Zebrafish [MESH]KDM2A integrates DNA and histone modification signals through a CXXC/P(epmc).pdf DeepDyve Pubget Overpricing