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10.1093/nar/gkw816 http://scihub22266oqcxt.onion/10.1093/nar/gkw816 C5388420!5388420 !28180316     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28180316 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (3 ): 1442-1454 Nephropedia Template TP {{tp|p=28180316 |t=2017. Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding |pdf=|usr=}}{{28180316 }} gab.com Text Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180316 #FOAvip RIG-I is an innate immune receptor that detects and responds to infection by deadly RNA viruses such as influenza, and Hepatitis C. In the cytoplasm, RIG-I is faced with a difficult challenge: it must sensitively detect viral RNA while ignoring the abundance of host RNA. It has been suggested that RIG-I has a ?proof-reading? mechanism for rejecting host RNA targets, and that disruptions of this selectivity filter give rise to autoimmune diseases. Here, we directly monitor RNA proof-reading by RIG-I and we show that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to the protein (Motif III). Mutations of this motif directly modulate proof-reading by eliminating or enhancing selectivity for viral RNA, with major implications for autoimmune disease and cancer. More broadly, the results provide a physical explanation for the ATP-gated behavior of SF2 RNA helicases and receptor proteins. Twit Text FOAVip Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28180316 #FOAvip English Wikipedia <ref>{{Cite pmid|28180316 }}</ref> Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding #MMPMID28180316 Fitzgerald ME ; Rawling DC ; Potapova O ; Ren X ; Kohlway A ; Pyle AM Nucleic Acids Res 2017[Feb]; 45 (3 ): 1442-1454 PMID28180316 show ga RIG-I is an innate immune receptor that detects and responds to infection by deadly RNA viruses such as influenza, and Hepatitis C. In the cytoplasm, RIG-I is faced with a difficult challenge: it must sensitively detect viral RNA while ignoring the abundance of host RNA. It has been suggested that RIG-I has a ?proof-reading? mechanism for rejecting host RNA targets, and that disruptions of this selectivity filter give rise to autoimmune diseases. Here, we directly monitor RNA proof-reading by RIG-I and we show that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to the protein (Motif III). Mutations of this motif directly modulate proof-reading by eliminating or enhancing selectivity for viral RNA, with major implications for autoimmune disease and cancer. More broadly, the results provide a physical explanation for the ATP-gated behavior of SF2 RNA helicases and receptor proteins. |Adenosine Triphosphatases/chemistry/genetics/metabolism [MESH] |Adenosine Triphosphate/*metabolism [MESH] |Amino Acid Substitution [MESH] |Autoimmunity [MESH] |Binding Sites/genetics [MESH] |DEAD Box Protein 58/genetics/immunology/*metabolism [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Models, Molecular [MESH] |Mutagenesis, Site-Directed [MESH] |Neoplasms/genetics/metabolism [MESH] |Protein Interaction Domains and Motifs [MESH] |RNA Viruses/genetics/immunology/pathogenicity [MESH] |RNA, Viral/chemistry/genetics/metabolism [MESH] |RNA/chemistry/genetics/*metabolism [MESH] |Receptors, Immunologic [MESH] |Receptors, Pattern Recognition/chemistry/genetics/metabolism [MESH]Selective RNA targeting and regulated signaling by RIG-I is controlled(epmc).pdf DeepDyve Pubget Overpricing