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10.1093/nar/gkw1051 http://scihub22266oqcxt.onion/10.1093/nar/gkw1051 C5388394!5388394 !28180295     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28180295 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2017 ; 45 (3 ): 1177-1185 Nephropedia Template TP {{tp|p=28180295 |t=2017. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron |pdf=|usr=}}{{28180295 }} gab.com Text A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180295 #FOAvip Genomic imprinting is an epigenetic regulation that leads to gene expression in a parent-of-origin specific manner. AFF3, the central component of the Super Elongation Complex-like 3 (SEC-L3), is enriched at both the intergenic-differentially methylated region (IG-DMR) and the Meg3 enhancer within the imprinted Dlk1-Dio3 locus to regulate the allele-specific gene expression in this locus. The localization of AFF3 to IG-DMR requires ZFP57. However, how AFF3 functions at the Meg3 enhancer in maintaining allele-specific gene expression remains unclear. Here, we demonstrate that AFF3 is associated with the Krüppel-like zinc finger protein ZFP281 in mouse embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron. Our genome-wide analyses further identify ZFP281 as a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes. Our study suggests that different zinc finger proteins can recruit AFF3 to different regulatory elements and differentially regulate the function of AFF3 in a context-dependent manner. Twit Text FOAVip A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180295 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28180295 #FOAvip English Wikipedia <ref>{{Cite pmid|28180295 }}</ref> A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron #MMPMID28180295 Wang Y ; Shen Y ; Dai Q ; Yang Q ; Zhang Y ; Wang X ; Xie W ; Luo Z ; Lin C Nucleic Acids Res 2017[Feb]; 45 (3 ): 1177-1185 PMID28180295 show ga Genomic imprinting is an epigenetic regulation that leads to gene expression in a parent-of-origin specific manner. AFF3, the central component of the Super Elongation Complex-like 3 (SEC-L3), is enriched at both the intergenic-differentially methylated region (IG-DMR) and the Meg3 enhancer within the imprinted Dlk1-Dio3 locus to regulate the allele-specific gene expression in this locus. The localization of AFF3 to IG-DMR requires ZFP57. However, how AFF3 functions at the Meg3 enhancer in maintaining allele-specific gene expression remains unclear. Here, we demonstrate that AFF3 is associated with the Krüppel-like zinc finger protein ZFP281 in mouse embryonic stem (ES) cells. ZFP281 recruits AFF3 to the Meg3 enhancer within the imprinted Dlk1-Dio3 locus, thus regulating the allele-specific expression of the Meg3 polycistron. Our genome-wide analyses further identify ZFP281 as a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes. Our study suggests that different zinc finger proteins can recruit AFF3 to different regulatory elements and differentially regulate the function of AFF3 in a context-dependent manner. |*Genomic Imprinting [MESH] |Animals [MESH] |Calcium-Binding Proteins [MESH] |Cells, Cultured [MESH] |Chromatin/*genetics/*metabolism [MESH] |DNA Methylation [MESH] |Embryonic Stem Cells/metabolism [MESH] |Enhancer Elements, Genetic [MESH] |Epigenesis, Genetic [MESH] |Intercellular Signaling Peptides and Proteins/genetics [MESH] |Iodide Peroxidase/genetics [MESH] |Mice [MESH] |Models, Genetic [MESH] |Nuclear Proteins/*metabolism [MESH] |RNA, Long Noncoding/*genetics [MESH]A permissive chromatin state regulated by ZFP281-AFF3 in controlling t(epmc).pdf DeepDyve Pubget Overpricing