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10.1093/nar/gkw1025 http://scihub22266oqcxt.onion/10.1093/nar/gkw1025 C5388390!5388390!28180298     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2017 ; 45 (3): 1144-58 Nephropedia Template TP {{tp|p=28180298|t=2017. Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy |pdf=|usr=}}{{28180298}} gab.com Text Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180298 #FOAvip Autophagy is an evolutionarily conserved cellular process that primarily participates in lysosome-mediated protein degradation. Although autophagy is a cytoplasmic event, how epigenetic pathways are involved in the regulation of autophagy remains incompletely understood. Here, we found that H2B monoubiquitination (H2Bub1) is down-regulated in cells under starvation conditions and that the decrease in H2Bub1 results in the activation of autophagy. We also identified that the deubiquitinase USP44 is responsible for the starvation-induced decrease in H2Bub1. Furthermore, the changes in H2Bub1 affect the transcription of genes involved in the regulation of autophagy. Therefore, this study reveals a novel epigenetic pathway for the regulation of autophagy through H2Bub1. Twit Text FOAVip Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=28180298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28180298 #FOAvip English Wikipedia <ref>{{Cite pmid|28180298}}</ref> Histone H2B monoubiquitination is a critical epigenetic switch for the regulation of autophagy #MMPMID28180298 Chen S; Jing Y; Kang X; Yang L; Wang DL; Zhang W; Zhang L; Chen P; Chang JF; Yang XM; Sun FL Nucleic Acids Res 2017[Feb]; 45 (3): 1144-58 PMID28180298show ga Autophagy is an evolutionarily conserved cellular process that primarily participates in lysosome-mediated protein degradation. Although autophagy is a cytoplasmic event, how epigenetic pathways are involved in the regulation of autophagy remains incompletely understood. Here, we found that H2B monoubiquitination (H2Bub1) is down-regulated in cells under starvation conditions and that the decrease in H2Bub1 results in the activation of autophagy. We also identified that the deubiquitinase USP44 is responsible for the starvation-induced decrease in H2Bub1. Furthermore, the changes in H2Bub1 affect the transcription of genes involved in the regulation of autophagy. Therefore, this study reveals a novel epigenetic pathway for the regulation of autophagy through H2Bub1. äHistone H2B monoubiquitination is a critical epigenetic switch for the(epmc).pdf DeepDyve Pubget Overpricing