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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Arrhythm 2017 ; 33 (2): 107-10 Nephropedia Template TP
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Effectiveness and safety of dabigatran versus warfarin in ?real-world? Japanese patients with atrial fibrillation: A single-center observational study #MMPMID28416975
Naganuma M; Shiga T; Nagao T; Suzuki A; Murasaki K; Hagiwara N
J Arrhythm 2017[Apr]; 33 (2): 107-10 PMID28416975show ga
Background: In ?real-world? practice, anticoagulant therapy is indicated for patients whose clinical profiles are not addressed in randomized clinical trials. We assessed the effectiveness and safety of dabigatran versus warfarin in ?real-world? Japanese patients with non-valvular atrial fibrillation (NVAF). Methods: Among 613 NVAF patients who initiated dabigatran or warfarin therapy during the period between 2011 and 2013, 362 patients were included in the study after propensity score adjustment. The median follow-up period was 1.3 years. The effectiveness and safety outcomes were thromboembolism and major bleeding, respectively. Results: The propensity-matched hazard ratios of thromboembolism and major bleeding with dabigatran were 1.03 (95% CI: 0.12-8.04, p=0.971) and 0.15 (95% CI: 0.01?0.90, p=0.037), respectively. Conclusions: The ability of dabigatran to prevent thromboembolism is comparable to that of warfarin; however, the major bleeding rate is lower with dabigatran in ?real-world? NVAF patients.