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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Retina
2017 ; 37
(4
): 687-693
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
VISUAL ACUITY OUTCOMES OF RANIBIZUMAB TREATMENT IN PATHOLOGIC MYOPIC EYES WITH
MACULAR RETINOSCHISIS AND CHOROIDAL NEOVASCULARIZATION
#MMPMID27533774
Ceklic L
; Munk MR
; Wolf-Schnurrbusch U
; Gekkieva M
; Wolf S
Retina
2017[Apr]; 37
(4
): 687-693
PMID27533774
show ga
PURPOSE: To investigate visual and morphological outcome in eyes with MRS and
choroidal neovascularization (CNV) secondary to pathologic myopia treated with
intravitreal (IVT) ranibizumab. METHODS: Post hoc analysis of the patients
included in the RADIANCE trial (n = 277) was performed to evaluate the impact of
MRS on the functional outcome in patients with myopic choroidal
neovascularization (mCNV) undergoing intravitreal ranibizumab injections.
RESULTS: Prevalence of MRS in pathologic myopia population is 6%. Respective
patients were generally older than patients without MRS. Study eyes with MRS at
baseline (BL) showed an initially poor treatment response after 3 months (mean
change in best corrected visual acuity (BCVA) was 2.8 ± 12.4 letters, P = 0.009).
After 12 months of treatment however, the mean change in BCVA was 7.1 ± 14.5
early treatment diabetic retinopathy study (ETDRS) letters (P = 0.025). Patients
with MRS at baseline received more intravitreal injections than the other
RADIANCE patients without MRS (MRS, n = 15 eyes: 5.8 ± 2.1 vs. RADIANCE non-MRS
[n = 207 eyes]: 4.0 ± 2.9; P = 0.0001). CONCLUSION: Improvement of visual acuity
is delayed and reduced after 3 months intravitreal ranibizumab in eyes with MRS
and myopic choroidal neovascularization compared to eyes without MRS. More
ranibizumab injections are needed in eyes with MRS to gain comparable BCVA at
Month 12.