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10.15537/smj.2017.3.16245 http://scihub22266oqcxt.onion/10.15537/smj.2017.3.16245 C5387898!5387898!28251217     free     free     free       Saudi+Med+J 2017 ; 38 (3): 237-44 Nephropedia Template TP {{tp|p=28251217|t=2017. Lymphangiogenesis and colorectal cancer |pdf=|usr=}}{{28251217}} gab.com Text Lymphangiogenesis and colorectal cancer JO: Saudi Med J http://www.kidney.de/pget.php?&tw=1&pmid=28251217 #FOAvip Lymphatic metastasis is an important event in the progress of metastasis in colorectal cancer (CRC). The purpose of this article is to assess the role of lymphangiogenesis on CRC. In peritumoral areas of CRC, the lymphatic microvessel density (LMVD) is higher than those in normal colorectal tissues. Morever, the high LMVD is correlated with DFS and local recurrence in CRC. The VEGF-C/VEGF-D/VEGFR-3 pathway, sonic hedgehog (Shh) signaling pathway and extracellular matrix (ECM) are involved in the regulation of lymphangiogenesis in CRC. Inhibition of the VEGF-C/VEGF-D/VEGFR-3 pathway by specific antibodies has been reported to efficiently inhibit experimental tumor lymphangiogenesis and metastasis in animal experiments. Although lymphangiogenesis has been reported to play an important role in the occurrence of colon cancer and to be associated with prognosis, it remains unclear whether it is a valid therapeutic target molecule. Further study of the potential of targeting this process for anti-lymphatic therapies is worthwhile. Twit Text FOAVip Lymphangiogenesis and colorectal cancer ????Saudi Med J http://www.kidney.de/pget.php?&tw=1&pmid=28251217 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28251217 #FOAvip English Wikipedia <ref>{{Cite pmid|28251217}}</ref> Lymphangiogenesis and colorectal cancer #MMPMID28251217 Huang C; Chen Y Saudi Med J 2017[Mar]; 38 (3): 237-44 PMID28251217show ga Lymphatic metastasis is an important event in the progress of metastasis in colorectal cancer (CRC). The purpose of this article is to assess the role of lymphangiogenesis on CRC. In peritumoral areas of CRC, the lymphatic microvessel density (LMVD) is higher than those in normal colorectal tissues. Morever, the high LMVD is correlated with DFS and local recurrence in CRC. The VEGF-C/VEGF-D/VEGFR-3 pathway, sonic hedgehog (Shh) signaling pathway and extracellular matrix (ECM) are involved in the regulation of lymphangiogenesis in CRC. Inhibition of the VEGF-C/VEGF-D/VEGFR-3 pathway by specific antibodies has been reported to efficiently inhibit experimental tumor lymphangiogenesis and metastasis in animal experiments. Although lymphangiogenesis has been reported to play an important role in the occurrence of colon cancer and to be associated with prognosis, it remains unclear whether it is a valid therapeutic target molecule. Further study of the potential of targeting this process for anti-lymphatic therapies is worthwhile. äLymphangiogenesis and colorectal cancer (epmc).pdf DeepDyve Pubget Overpricing