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2017 ; 2017
(ä): 8053474
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Intravenous Lidocaine: Old-School Drug, New Purpose-Reduction of Intractable Pain
in Patients with Chemotherapy Induced Peripheral Neuropathy
#MMPMID28458593
van den Heuvel SAS
; van der Wal SEI
; Smedes LA
; Radema SA
; van Alfen N
; Vissers KCP
; Steegers MAH
Pain Res Manag
2017[]; 2017
(ä): 8053474
PMID28458593
show ga
Background. Treatment of intractable pain due to chemotherapy induced peripheral
neuropathy (CIPN) is a challenge. Intravenous (iv) lidocaine has shown to be a
treatment option for neuropathic pain of different etiologies. Methods. Lidocaine
(1.5?mg/kg in 10 minutes followed by 1.5?mg/kg/h over 5 hours) was administered
in nine patients with CIPN, and analgesic effect was evaluated during infusion
and after discharge. The immediate effect of lidocaine on pressure pain
thresholds (PPT) and the extent of the stocking and glove distribution of sensory
abnormalities (cold and pinprick) were assessed. Results. Lidocaine had a
significant direct analgesic effect in 8 out of 9 patients (P = 0.01) with a pain
intensity difference of >30%. Pain reduction persisted in 5 patients for an
average of 23 days. Lidocaine did not influence mean PPT, but there was a
tendency that the extent of sensory abnormalities decreased after lidocaine.
Conclusion. Iv lidocaine has direct analgesic effect in CIPN with a moderate
long-term effect and seems to influence the area of cold and pinprick perception.
Additional research is needed, using a control group and larger sample sizes to
confirm these results.