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10.1155/2017/6947034

http://scihub22266oqcxt.onion/10.1155/2017/6947034
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C5387815!5387815!28458618
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suck abstract from ncbi


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pmid28458618      Bioinorg+Chem+Appl 2017 ; 2017 (ä): ä
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  • A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? #MMPMID28458618
  • Papakonstantinou VD; Lagopati N; Tsilibary EC; Demopoulos CA; Philippopoulos AI
  • Bioinorg Chem Appl 2017[]; 2017 (ä): ä PMID28458618show ga
  • In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.
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