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10.1038/srep46307 http://scihub22266oqcxt.onion/10.1038/srep46307 C5387733!5387733!28397812     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28397812&cmd=llinks): Failed to open stream: HTTP request failed! 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Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation |pdf=|usr=}}{{28397812}} gab.com Text Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28397812 #FOAvip Atrial Fibrillation (AF) is common in the elderly and Sestrins (Sesns) have been suggested to prevent age-related pathologies. The aim of this study was to investigate the effects of Sesns in AF. Clinical data were collected and a small sample of atrial appendage and atrium was obtained from patients undergoing valve repairment. The expression of Sesn1, Sesn2, and Sesn3 was significantly higher in patients with permanent atrial fibrillation (PmAF) than that in sinus rhythm (SR), and further greater in the left atrium than the right in PmAF patients. Superoxide anion and malondialdehyde were enhanced and positively correlated to the protein expression of Sesn1/2/3. Reactive oxygen species (ROS) production and Ca2+ overload were significantly decreased and cell survival was enhanced by overexpression of Sesns 1/2/3 in cultured HL-1 cells. Conversely, knockdown of Sesn1/2/3 resulted in significantly increased ROS and Ca2+ overload. In addition, the overexpression of Sesn1/2 significantly reduced the proliferation of fibroblasts, as well as decreased the protein expression of collagen and fibronectin1 in angiotensin II-stimulated cardiac fibroblasts. Our study demonstrated for the first time that Sesns expression is significantly up-regulated in AF, which therefore may protect hearts against oxidative damage and atrial fibrosis. Twit Text FOAVip Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28397812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28397812 #FOAvip English Wikipedia <ref>{{Cite pmid|28397812}}</ref> Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation #MMPMID28397812 Dong Z; Lin C; Liu Y; Jin H; Wu H; Li Z; Sun L; Zhang L; Hu X; Wei Y; Wang C; Han W Sci Rep 2017[]; 7 (ä): ä PMID28397812show ga Atrial Fibrillation (AF) is common in the elderly and Sestrins (Sesns) have been suggested to prevent age-related pathologies. The aim of this study was to investigate the effects of Sesns in AF. Clinical data were collected and a small sample of atrial appendage and atrium was obtained from patients undergoing valve repairment. The expression of Sesn1, Sesn2, and Sesn3 was significantly higher in patients with permanent atrial fibrillation (PmAF) than that in sinus rhythm (SR), and further greater in the left atrium than the right in PmAF patients. Superoxide anion and malondialdehyde were enhanced and positively correlated to the protein expression of Sesn1/2/3. Reactive oxygen species (ROS) production and Ca2+ overload were significantly decreased and cell survival was enhanced by overexpression of Sesns 1/2/3 in cultured HL-1 cells. Conversely, knockdown of Sesn1/2/3 resulted in significantly increased ROS and Ca2+ overload. In addition, the overexpression of Sesn1/2 significantly reduced the proliferation of fibroblasts, as well as decreased the protein expression of collagen and fibronectin1 in angiotensin II-stimulated cardiac fibroblasts. Our study demonstrated for the first time that Sesns expression is significantly up-regulated in AF, which therefore may protect hearts against oxidative damage and atrial fibrosis. äUpregulation of sestrins protect atriums against oxidative damage and (epmc).pdf DeepDyve Pubget Overpricing