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10.1038/celldisc.2017.3 http://scihub22266oqcxt.onion/10.1038/celldisc.2017.3 C5387711!5387711!28417011     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Discov 2017 ; 3 (ä): 17003- Nephropedia Template TP {{tp|p=28417011|t=2017. Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/?-catenin transcriptional activity |pdf=|usr=}}{{28417011}} gab.com Text Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/ -catenin transcriptional activity JO: Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=28417011 #FOAvip Wnt/?-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/?-catenin signaling. Here, we identified CARF as the cellular target of NC043. We found that NC043 binds directly to CARF through forming a covalent bond with the Cys-516 residue of CARF. Further study revealed that CARF interacts with Dvl, which potentiates the Dvl?c-Jun??-catenin?TCF transcriptional complex and thus promotes Wnt signaling activation. NC043 could disrupt the interaction between CARF and Dvl, thereby impairing Wnt signal transduction. In line with this, knockdown of CARF in zebrafish leads to impairment of embryonic development, hematopoietic stem cell generation and caudal fin regeneration. Collectively, we identified CARF as the cellular target of NC043 and revealed CARF as a positive regulator of Wnt/?-catenin signal transduction. Twit Text FOAVip Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/ -catenin transcriptional activity ????Cell Discov http://www.kidney.de/pget.php?&tw=1&pmid=28417011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28417011 #FOAvip English Wikipedia <ref>{{Cite pmid|28417011}}</ref> Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/?-catenin transcriptional activity #MMPMID28417011 He X; Zhang W; Yan C; Nie F; Li C; Liu X; Fei C; Li S; Song X; Jia Y; Zeng R; Wu D; Pan W; Hao X; Li L Cell Discov 2017[]; 3 (ä): 17003- PMID28417011show ga Wnt/?-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/?-catenin signaling. Here, we identified CARF as the cellular target of NC043. We found that NC043 binds directly to CARF through forming a covalent bond with the Cys-516 residue of CARF. Further study revealed that CARF interacts with Dvl, which potentiates the Dvl?c-Jun??-catenin?TCF transcriptional complex and thus promotes Wnt signaling activation. NC043 could disrupt the interaction between CARF and Dvl, thereby impairing Wnt signal transduction. In line with this, knockdown of CARF in zebrafish leads to impairment of embryonic development, hematopoietic stem cell generation and caudal fin regeneration. Collectively, we identified CARF as the cellular target of NC043 and revealed CARF as a positive regulator of Wnt/?-catenin signal transduction. äChemical biology reveals CARF as a positive regulator of canonical Wnt(epmc).pdf DeepDyve Pubget Overpricing