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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Mol+Med
2017 ; 21
(5
): 993-1012
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Biomarkers of systemic lupus erythematosus identified using mass
spectrometry-based proteomics: a systematic review
#MMPMID27878954
Nicolaou O
; Kousios A
; Hadjisavvas A
; Lauwerys B
; Sokratous K
; Kyriacou K
J Cell Mol Med
2017[May]; 21
(5
): 993-1012
PMID27878954
show ga
Advances in mass spectrometry technologies have created new opportunities for
discovering novel protein biomarkers in systemic lupus erythematosus (SLE). We
performed a systematic review of published reports on proteomic biomarkers
identified in SLE patients using mass spectrometry-based proteomics and highlight
their potential disease association and clinical utility. Two electronic
databases, MEDLINE and EMBASE, were systematically searched up to July 2015. The
methodological quality of studies included in the review was performed according
to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.
Twenty-five studies were included in the review, identifying 241 SLE candidate
proteomic biomarkers related to various aspects of the disease including disease
diagnosis and activity or pinpointing specific organ involvement. Furthermore, 13
of the 25 studies validated their results for a selected number of biomarkers in
an independent cohort, resulting in the validation of 28 candidate biomarkers. It
is noteworthy that 11 candidate biomarkers were identified in more than one
study. A significant number of potential proteomic biomarkers that are related to
a number of aspects of SLE have been identified using mass spectrometry proteomic
approaches. However, further studies are required to assess the utility of these
biomarkers in routine clinical practice.