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10.1111/jcmm.13024 http://scihub22266oqcxt.onion/10.1111/jcmm.13024 C5387173!5387173!27860245     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (5): 848-59 Nephropedia Template TP {{tp|p=27860245|t=2017. Telocytes: a potential defender in the spleen of Npc1 mutant mice |pdf=|usr=}}{{27860245}} gab.com Text Telocytes: a potential defender in the spleen of Npc1 mutant mice JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27860245 #FOAvip Niemann?Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1?/?), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1?/? mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c?Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1?/? mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1?/? spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages. Twit Text FOAVip Telocytes: a potential defender in the spleen of Npc1 mutant mice ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27860245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27860245 #FOAvip English Wikipedia <ref>{{Cite pmid|27860245}}</ref> Telocytes: a potential defender in the spleen of Npc1 mutant mice #MMPMID27860245 Zhang B; Yang C; Qiao L; Li Q; Wang C; Yan X; Lin J J Cell Mol Med 2017[May]; 21 (5): 848-59 PMID27860245show ga Niemann?Pick disease, type C1 (Npc1), is an atypical lysosomal storage disorder caused by autosomal recessive inheritance of mutations in Npc1 gene. In the Npc1 mutant mice (Npc1?/?), the initial manifestation is enlarged spleen, concomitant with free cholesterol accumulation. Telocytes (TCs), a novel type of interstitial cell, exist in a variety of tissues including spleen, presumably thought to be involved in many biological processes such as nursing stem cells and recruiting inflammatory cells. In this study, we found that the spleen is significantly enlarged in Npc1?/? mice, and the results from transmission electron microscopy examination and immunostaining using three different TCs markers, c?Kit, CD34 and Vimentin revealed significantly increased splenic TCs in Npc1?/? mice. Furthermore, hematopoietic stem cells and macrophages were also elevated in Npc1?/? spleen. Taken together, our data indicate that splenic TCs might alleviate the progress of splenic malfunction via recruiting hematopoietic stem cells and macrophages. äTelocytes: a potential defender in the spleen of Npc1 mutant mice (epmc).pdf DeepDyve Pubget Overpricing