Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/cam4.1042 http://scihub22266oqcxt.onion/10.1002/cam4.1042 C5387164!5387164!28332314     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Med 2017 ; 6 (4): 749-60 Nephropedia Template TP {{tp|p=28332314|t=2017. The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma |pdf=|usr=}}{{28332314}} gab.com Text The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma JO: Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=28332314 #FOAvip Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol?cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real?time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1?fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan?Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence?free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the ??fetoprotein (AFP) level. The patient subgroup with higher AFP levels (?20 ng/mL) exhibited significant differences in 5?year overall (18.5% vs. 67.9%) and recurrence?free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment. Twit Text FOAVip The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma ????Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=28332314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28332314 #FOAvip English Wikipedia <ref>{{Cite pmid|28332314}}</ref> The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma #MMPMID28332314 Park E; Kim S; Lee J; Kim Y; Lee D; Cho E; Park S; Han CJ; Kim B; Choi DW; Yoo YD; Yu A; Lee JW; Jang JJ; Park YN; Suh K; Lee K Cancer Med 2017[Apr]; 6 (4): 749-60 PMID28332314show ga Alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. Ubiquinol?cytochrome c reductase hinge protein (UQCRH) consists of the cytochrome bc1 complex serving respiration in mitochondria. In the present study, we analyzed UQCRH abnormalities in hepatocellular carcinoma (HCC) and its association with clinical outcomes of patients. UQCRH expression in HCC was determined via semiquantitative and quantitative real?time reverse transcriptase polymerase chain reaction of 96 surgically resected HCC tissues positive for hepatitis B virus surface antigen. UQCRH was frequently overexpressed in HCC tissues (46.8%, based on 2.1?fold cutoff). UQCRH overexpression was observed in HCCs with larger tumor size, poorer differentiation, or vascular invasion. Kaplan?Meier analysis revealed significantly shorter overall (P = 0.005) and recurrence?free survival (P = 0.027) in patients with tumors overexpressing UQCRH. The prognostic impact of UQCRH was significant in subgroups of patients divided according to the ??fetoprotein (AFP) level. The patient subgroup with higher AFP levels (?20 ng/mL) exhibited significant differences in 5?year overall (18.5% vs. 67.9%) and recurrence?free survival rates (11.1% vs. 46.4%) between groups with and without UQCRH overexpression. In contrast, no marked survival differences were observed between subgroups with lower AFP levels (<20 ng/mL). Multivariate analysis defined UQCRH as an independent poor prognostic factor. Conclusively, our results indicate that UQCRH overexpression is correlated with poor outcomes of HCC patients. Furthermore, in patients grouped as high risk based on elevated AFP, lack of UQCRH overexpression could be a useful indicator for clinical treatment. äThe mitochondrial hinge protein, UQCRH, is a novel prognostic factor f(epmc).pdf DeepDyve Pubget Overpricing