Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/jcmm.13037 http://scihub22266oqcxt.onion/10.1111/jcmm.13037 C5387123!5387123!28063200     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2017 ; 21 (5): 975-85 Nephropedia Template TP {{tp|p=28063200|t=2017. Effects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ double?positive T lymphocytes in a mouse model of systemic lupus erythematosus |pdf=|usr=}}{{28063200}} gab.com Text Effects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ double positive T lymphocytes in a mouse model of systemic lupus erythematosus JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip This study aims to explore effects of 1,25(OH)2D3 and vitamin D receptor (VDR) on peripheral CD4+/CD8+ double?positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL?LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)2D3), the 1,25(OH)2D3 group (SLE mice, feeding with 1,25(OH)2D3), the VDR?knock?in + 1,25(OH)2D3 group (SLE mice, VDR?knock?in, feeding with 1,25(OH)2D3) and the VDR?knockout group (normal mice, VDR?knockout, without feeding with 1,25(OH)2D3) (n = 10 per group). Levels of T lymphocytes were measured by flow cytometry. The mRNA and proteins expressions of inflammatory factors were measured by qRT?PCR and ELISA. Extracellular signal?regulated kinase?1/2 (ERK1/2) expression was measured by Western blotting. Compared with normal mice, SLE mice showed reduced levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes. The levels of SLE?related indicators all increased significantly, followed with severe skin ulcers and urinary system infection. With the increase in time, skin ulcers and urinary system infection were significantly improved, levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes increased, and levels of SLE?related indicators all decreased in the 1,25(OH)2D3 group. There were no significant changes in bioindicators in the control and the VDR?knock?in + 1,25(OH)2D3 groups. The symptoms of SLE gradually occurred in the VDR?knockout group. This study demonstrates that VDR and 1,25(OH)2D3 could elevate CD4+/CD8+ DP T lymphocytes and reduce expressions of inflammatory factors, thus inhibiting the development and progression of SLE. Twit Text FOAVip Effects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ double positive T lymphocytes in a mouse model of systemic lupus erythematosus ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip English Wikipedia <ref>{{Cite pmid|28063200}}</ref> Effects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ double?positive T lymphocytes in a mouse model of systemic lupus erythematosus #MMPMID28063200 Ding Y; Liao W; He X; Xiang W J Cell Mol Med 2017[May]; 21 (5): 975-85 PMID28063200show ga This study aims to explore effects of 1,25(OH)2D3 and vitamin D receptor (VDR) on peripheral CD4+/CD8+ double?positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL?LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)2D3), the 1,25(OH)2D3 group (SLE mice, feeding with 1,25(OH)2D3), the VDR?knock?in + 1,25(OH)2D3 group (SLE mice, VDR?knock?in, feeding with 1,25(OH)2D3) and the VDR?knockout group (normal mice, VDR?knockout, without feeding with 1,25(OH)2D3) (n = 10 per group). Levels of T lymphocytes were measured by flow cytometry. The mRNA and proteins expressions of inflammatory factors were measured by qRT?PCR and ELISA. Extracellular signal?regulated kinase?1/2 (ERK1/2) expression was measured by Western blotting. Compared with normal mice, SLE mice showed reduced levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes. The levels of SLE?related indicators all increased significantly, followed with severe skin ulcers and urinary system infection. With the increase in time, skin ulcers and urinary system infection were significantly improved, levels of CD4+, CD4+/CD8+ ratio, and DP lymphocytes increased, and levels of SLE?related indicators all decreased in the 1,25(OH)2D3 group. There were no significant changes in bioindicators in the control and the VDR?knock?in + 1,25(OH)2D3 groups. The symptoms of SLE gradually occurred in the VDR?knockout group. This study demonstrates that VDR and 1,25(OH)2D3 could elevate CD4+/CD8+ DP T lymphocytes and reduce expressions of inflammatory factors, thus inhibiting the development and progression of SLE. äEffects of 1,25(OH)2D3 and vitamin D receptor on peripheral CD4+/CD8+ (epmc).pdf DeepDyve Pubget Overpricing