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10.1111/jcmm.13037 http://scihub22266oqcxt.onion/10.1111/jcmm.13037 C5387123!5387123 !28063200     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28063200 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effects of 1,25(OH)(2) D(3) and vitamin D receptor on peripheral CD4(+) /CD8(+) double-positive T lymphocytes in a mouse model of systemic lupus erythematosus |pdf=|usr=}}{{28063200 }} gab.com Text Effects of 1,25(OH)(2) D(3) and vitamin D receptor on peripheral CD4(+) /CD8(+) double-positive T lymphocytes in a mouse model of systemic lupus erythematosus JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip This study aims to explore effects of 1,25(OH)(2) D(3) and vitamin D receptor (VDR) on peripheral CD4(+) /CD8(+) double-positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL-LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)(2) D(3) ), the 1,25(OH)(2) D(3) group (SLE mice, feeding with 1,25(OH)(2) D(3) ), the VDR-knock-in + 1,25(OH)(2) D(3) group (SLE mice, VDR-knock-in, feeding with 1,25(OH)(2) D(3) ) and the VDR-knockout group (normal mice, VDR-knockout, without feeding with 1,25(OH)(2) D(3) ) (n = 10 per group). Levels of T lymphocytes were measured by flow cytometry. The mRNA and proteins expressions of inflammatory factors were measured by qRT-PCR and ELISA. Extracellular signal-regulated kinase-1/2 (ERK1/2) expression was measured by Western blotting. Compared with normal mice, SLE mice showed reduced levels of CD4(+) , CD4(+) /CD8(+) ratio, and DP lymphocytes. The levels of SLE-related indicators all increased significantly, followed with severe skin ulcers and urinary system infection. With the increase in time, skin ulcers and urinary system infection were significantly improved, levels of CD4(+) , CD4(+) /CD8(+) ratio, and DP lymphocytes increased, and levels of SLE-related indicators all decreased in the 1,25(OH)(2) D(3) group. There were no significant changes in bioindicators in the control and the VDR-knock-in + 1,25(OH)(2) D(3) groups. The symptoms of SLE gradually occurred in the VDR-knockout group. This study demonstrates that VDR and 1,25(OH)(2) D(3) could elevate CD4(+) /CD8(+) DP T lymphocytes and reduce expressions of inflammatory factors, thus inhibiting the development and progression of SLE. Twit Text FOAVip Effects of 1,25(OH)(2) D(3) and vitamin D receptor on peripheral CD4(+) /CD8(+) double-positive T lymphocytes in a mouse model of systemic lupus erythematosus ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28063200 #FOAvip English Wikipedia <ref>{{Cite pmid|28063200 }}</ref> Effects of 1,25(OH)(2) D(3) and vitamin D receptor on peripheral CD4(+) /CD8(+) double-positive T lymphocytes in a mouse model of systemic lupus erythematosus #MMPMID28063200 Ding Y ; Liao W ; He XJ ; Xiang W J Cell Mol Med 2017[May]; 21 (5 ): 975-985 PMID28063200 show ga This study aims to explore effects of 1,25(OH)(2) D(3) and vitamin D receptor (VDR) on peripheral CD4(+) /CD8(+) double-positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL-LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)(2) D(3) ), the 1,25(OH)(2) D(3) group (SLE mice, feeding with 1,25(OH)(2) D(3) ), the VDR-knock-in + 1,25(OH)(2) D(3) group (SLE mice, VDR-knock-in, feeding with 1,25(OH)(2) D(3) ) and the VDR-knockout group (normal mice, VDR-knockout, without feeding with 1,25(OH)(2) D(3) ) (n = 10 per group). Levels of T lymphocytes were measured by flow cytometry. The mRNA and proteins expressions of inflammatory factors were measured by qRT-PCR and ELISA. Extracellular signal-regulated kinase-1/2 (ERK1/2) expression was measured by Western blotting. Compared with normal mice, SLE mice showed reduced levels of CD4(+) , CD4(+) /CD8(+) ratio, and DP lymphocytes. The levels of SLE-related indicators all increased significantly, followed with severe skin ulcers and urinary system infection. With the increase in time, skin ulcers and urinary system infection were significantly improved, levels of CD4(+) , CD4(+) /CD8(+) ratio, and DP lymphocytes increased, and levels of SLE-related indicators all decreased in the 1,25(OH)(2) D(3) group. There were no significant changes in bioindicators in the control and the VDR-knock-in + 1,25(OH)(2) D(3) groups. The symptoms of SLE gradually occurred in the VDR-knockout group. This study demonstrates that VDR and 1,25(OH)(2) D(3) could elevate CD4(+) /CD8(+) DP T lymphocytes and reduce expressions of inflammatory factors, thus inhibiting the development and progression of SLE. |Animals [MESH] |CD4-Positive T-Lymphocytes/drug effects/*immunology [MESH] |CD8-Positive T-Lymphocytes/drug effects/*immunology [MESH] |Calcitriol/*pharmacology [MESH] |Cytokines/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Fluorescent Antibody Technique [MESH] |Lupus Erythematosus, Systemic/blood/*immunology/pathology [MESH] |Mice, Inbred MRL lpr [MESH] |Phosphorylation/drug effects [MESH] |RNA, Messenger/genetics/metabolism [MESH]Effects of 1,25(OH)(2) D(3) and vitamin D receptor on peripheral CD4(+(epmc).pdf DeepDyve Pubget Overpricing