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10.1016/j.jaut.2017.01.003 http://scihub22266oqcxt.onion/10.1016/j.jaut.2017.01.003 C5386815!5386815!28126203     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Autoimmun 2017 ; 79 (ä): 39-52 Nephropedia Template TP {{tp|p=28126203|t=2017. Skin-derived TSLP systemically expands regulatory T cells |pdf=|usr=}}{{28126203}} gab.com Text Skin-derived TSLP systemically expands regulatory T cells JO: J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=28126203 #FOAvip Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical for limiting inappropriate activation of T cells. Hence, the expansion of Tregs is an attractive strategy for the treatment of autoimmune diseases. Here, we demonstrate that the skin possesses the remarkable capacity to systemically expand Treg numbers by producing thymic stromal lymphopoietin (TSLP) in response to vitamin D receptor stimulation. An ~2-fold increase in the proportion and absolute number of Tregs was observed in mice treated topically but not systemically with the Vitamin D3 analog MC903. This expansion of Tregs was dependent on TSLP receptor signaling but not on VDR signaling in hematopoietic cells. However, TSLP receptor expression by Tregs was not required for their proliferation. Rather, skin-derived TSLP promoted Treg expansion through dendritic cells. Importantly, treatment of skin with MC903 significantly lowered the incidence of autoimmune diabetes in non-obese diabetic mice and attenuated disease score in experimental autoimmune encephalomyelitis. Together, these data demonstrate that the skin has the remarkable potential to control systemic immune responses and that Vitamin D-mediated stimulation of skin could serve as a novel strategy to therapeutically modulate the systemic immune system for the treatment of autoimmunity. Twit Text FOAVip Skin-derived TSLP systemically expands regulatory T cells ????J Autoimmun http://www.kidney.de/pget.php?&tw=1&pmid=28126203 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28126203 #FOAvip English Wikipedia <ref>{{Cite pmid|28126203}}</ref> Skin-derived TSLP systemically expands regulatory T cells #MMPMID28126203 Leichner TM; Satake A; Harrison VS; Tanaka Y; Archambault A; Kim BS; Siracusa MC; Leonard WJ; Naji A; Wu GF; Artis D; Kambayashi T J Autoimmun 2017[May]; 79 (ä): 39-52 PMID28126203show ga Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical for limiting inappropriate activation of T cells. Hence, the expansion of Tregs is an attractive strategy for the treatment of autoimmune diseases. Here, we demonstrate that the skin possesses the remarkable capacity to systemically expand Treg numbers by producing thymic stromal lymphopoietin (TSLP) in response to vitamin D receptor stimulation. An ~2-fold increase in the proportion and absolute number of Tregs was observed in mice treated topically but not systemically with the Vitamin D3 analog MC903. This expansion of Tregs was dependent on TSLP receptor signaling but not on VDR signaling in hematopoietic cells. However, TSLP receptor expression by Tregs was not required for their proliferation. Rather, skin-derived TSLP promoted Treg expansion through dendritic cells. Importantly, treatment of skin with MC903 significantly lowered the incidence of autoimmune diabetes in non-obese diabetic mice and attenuated disease score in experimental autoimmune encephalomyelitis. Together, these data demonstrate that the skin has the remarkable potential to control systemic immune responses and that Vitamin D-mediated stimulation of skin could serve as a novel strategy to therapeutically modulate the systemic immune system for the treatment of autoimmunity. äSkin-derived TSLP systemically expands regulatory T cells (epmc).pdf DeepDyve Pubget Overpricing