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10.18632/oncotarget.14723

http://scihub22266oqcxt.onion/10.18632/oncotarget.14723
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C5386776!5386776!28107201
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suck abstract from ncbi


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pmid28107201      Oncotarget 2017 ; 8 (12): 20452-61
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  • Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies #MMPMID28107201
  • Feng Y; Zhou L; Sun X; Li Q
  • Oncotarget 2017[Mar]; 8 (12): 20452-61 PMID28107201show ga
  • The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a ?caretaker? gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This report reviews the anti-tumorigenic mechanisms of HIPK2, which include promotion of apoptosis, inhibition of angiogenesis in hypoxia, prevention of tumor invasion/metastasis and attenuation of multidrug resistance in cancer. Additionally, we summarize conditions or factors that may increase HIPK2 activity.
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