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10.18632/oncotarget.15384 http://scihub22266oqcxt.onion/10.18632/oncotarget.15384 C5386747!5386747!28223545     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (12): 20103-12 Nephropedia Template TP {{tp|p=28223545|t=2017. Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha |pdf=|usr=}}{{28223545}} gab.com Text Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28223545 #FOAvip Ring finger protein 6 (RNF6) is a key oncogene in both prostate cancer and leukemia, but its role is elusive in breast cancer. In the present study, we found that RNF6 was overexpressed in more than 70% of breast cancer tissues and it was associated with overall survival. RNF6 increased breast cancer cell proliferation, migration and reduced cell sensitivity to doxorubicin. Further studies showed that RNF6 was closely associated with increased expression of estrogen receptor, a critical factor in the development of breast cancers. RNF6 was found to induce ER? expression and increased its stability. In doxorubicin-resistant breast cancer cells, RNF6 was found to be elevated in association with increased ER? and anti-apoptotic Bcl-xL, but not pro-apoptotic Bim-1. In consistence with this finding, overexpression of ER? led to increased Bcl-xL but had no effects on Bim-1. Therefore, this study demonstrated that there exists an RNF6/ER?/Bcl-xL axle in breast cancer which promotes cancer cell proliferation and survival. Targeting the RNF6/ER?/Bcl-xL axle could be a promising strategy in the treatment of breast cancer. Twit Text FOAVip Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28223545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28223545 #FOAvip English Wikipedia <ref>{{Cite pmid|28223545}}</ref> Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha #MMPMID28223545 Zeng Y; Xu X; Wang S; Zhang Z; Liu Y; Han K; Cao B; Mao X Oncotarget 2017[Mar]; 8 (12): 20103-12 PMID28223545show ga Ring finger protein 6 (RNF6) is a key oncogene in both prostate cancer and leukemia, but its role is elusive in breast cancer. In the present study, we found that RNF6 was overexpressed in more than 70% of breast cancer tissues and it was associated with overall survival. RNF6 increased breast cancer cell proliferation, migration and reduced cell sensitivity to doxorubicin. Further studies showed that RNF6 was closely associated with increased expression of estrogen receptor, a critical factor in the development of breast cancers. RNF6 was found to induce ER? expression and increased its stability. In doxorubicin-resistant breast cancer cells, RNF6 was found to be elevated in association with increased ER? and anti-apoptotic Bcl-xL, but not pro-apoptotic Bim-1. In consistence with this finding, overexpression of ER? led to increased Bcl-xL but had no effects on Bim-1. Therefore, this study demonstrated that there exists an RNF6/ER?/Bcl-xL axle in breast cancer which promotes cancer cell proliferation and survival. Targeting the RNF6/ER?/Bcl-xL axle could be a promising strategy in the treatment of breast cancer. äRing finger protein 6 promotes breast cancer cell proliferation by sta(epmc).pdf DeepDyve Pubget Overpricing