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10.18632/oncotarget.14752 http://scihub22266oqcxt.onion/10.18632/oncotarget.14752 C5386708!5386708 !28121625     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28121625 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (12 ): 19592-19608 Nephropedia Template TP {{tp|p=28121625 |t=2017. Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer |pdf=|usr=}}{{28121625 }} gab.com Text Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28121625 #FOAvip Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They may drive tumor progression, although the mechanisms involved are still poorly understood. Exosomes have emerged as important mediators of intercellular communication in cancer. They mediate horizontal transfer of microRNAs (miRs), mRNAs and proteins, thus affecting breast cancer progression. Differential expression profile analysis identified three miRs (miRs -21, -378e, and -143) increased in exosomes from CAFs as compared from normal fibroblasts. Immunofluorescence indicated that exosomes may be transferred from CAFs to breast cancer cells, releasing their cargo miRs. Breast cancer cells (BT549, MDA-MB-231, and T47D lines) exposed to CAF exosomes or transfected with those miRs exhibited a significant increased capacity to form mammospheres, increased stem cell and epithelial-mesenchymal transition (EMT) markers, and anchorage-independent cell growth. These effects were reverted by transfection with anti-miRs. Similarly to CAF exosomes, normal fibroblast exosomes transfected with miRs -21, -378e, and -143 promoted the stemness and EMT phenotype of breast cancer cells. Thus, we provided evidence for the first time of the role of CAF exosomes and their miRs in the induction of the stemness and EMT phenotype in different breast cancer cell lines. Indeed, CAFs strongly promote the development of an aggressive breast cancer cell phenotype. Twit Text FOAVip Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28121625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28121625 #FOAvip English Wikipedia <ref>{{Cite pmid|28121625 }}</ref> Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer #MMPMID28121625 Donnarumma E ; Fiore D ; Nappa M ; Roscigno G ; Adamo A ; Iaboni M ; Russo V ; Affinito A ; Puoti I ; Quintavalle C ; Rienzo A ; Piscuoglio S ; Thomas R ; Condorelli G Oncotarget 2017[Mar]; 8 (12 ): 19592-19608 PMID28121625 show ga Cancer-associated fibroblasts (CAFs) are the major components of the tumor microenvironment. They may drive tumor progression, although the mechanisms involved are still poorly understood. Exosomes have emerged as important mediators of intercellular communication in cancer. They mediate horizontal transfer of microRNAs (miRs), mRNAs and proteins, thus affecting breast cancer progression. Differential expression profile analysis identified three miRs (miRs -21, -378e, and -143) increased in exosomes from CAFs as compared from normal fibroblasts. Immunofluorescence indicated that exosomes may be transferred from CAFs to breast cancer cells, releasing their cargo miRs. Breast cancer cells (BT549, MDA-MB-231, and T47D lines) exposed to CAF exosomes or transfected with those miRs exhibited a significant increased capacity to form mammospheres, increased stem cell and epithelial-mesenchymal transition (EMT) markers, and anchorage-independent cell growth. These effects were reverted by transfection with anti-miRs. Similarly to CAF exosomes, normal fibroblast exosomes transfected with miRs -21, -378e, and -143 promoted the stemness and EMT phenotype of breast cancer cells. Thus, we provided evidence for the first time of the role of CAF exosomes and their miRs in the induction of the stemness and EMT phenotype in different breast cancer cell lines. Indeed, CAFs strongly promote the development of an aggressive breast cancer cell phenotype. |*Epithelial-Mesenchymal Transition [MESH] |Apoptosis [MESH] |Biomarkers, Tumor/genetics [MESH] |Breast Neoplasms/genetics/*pathology [MESH] |Cancer-Associated Fibroblasts [MESH] |Cell Proliferation [MESH] |Exosomes/*genetics [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |MicroRNAs/*genetics [MESH] |Neoplasm Staging [MESH] |Phenotype [MESH] |Prognosis [MESH] |Signal Transduction [MESH] |Tumor Cells, Cultured [MESH]Cancer-associated fibroblasts release exosomal microRNAs that dictate (epmc).pdf DeepDyve Pubget Overpricing