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2017 ; 8
(12
): 19566-19576
Nephropedia Template TP
Zhang X
; Yang M
; Shi H
; Hu J
; Wang Y
; Sun Z
; Xu S
Oncotarget
2017[Mar]; 8
(12
): 19566-19576
PMID28223537
show ga
Reduced expression of E-cadherin was observed in renal cell carcinoma (RCC).
However, its potential clinical value and correlation with WNT/?-catenin
signaling in RCC progression was still unclear. Immunohistochemical staining was
performed in RCC tissue microarray to examine the expression status and prognosis
value of E-cadherin and ?-catenin. The potential role of E-cadherin in ?-catenin
translocation was analyzed with immunobloting assays. A significant negative
correlation was observed between E-cadherin and ?-catenin expression in RCC
tissues. E-cadherin inhibits ?-catenin translocation from membrane to cytoplasm
in RCC tissues, which was an important step for WNT/?-catenin signaling. Reduced
E-cadherin expression was associated with poor prognosis. More importantly,
E-cadherin-/?-catenin+ was an independent detrimental factor for survival
estimation of RCC patients. Reduced E-cadherin expression in RCC promoted cancer
progression via WNT/?-catenin signaling pathway activation. E-cadherin/?-catenin
provides a valuable prognosis marker for RCC, which may be an effective target
for RCC therapy.
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