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10.18632/oncotarget.8627

http://scihub22266oqcxt.onion/10.18632/oncotarget.8627
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suck abstract from ncbi


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pmid27078843
      Oncotarget 2017 ; 8 (12 ): 18699-18711
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  • Association of coffee consumption with risk of colorectal cancer: a meta-analysis of prospective cohort studies #MMPMID27078843
  • Gan Y ; Wu J ; Zhang S ; Li L ; Cao S ; Mkandawire N ; Ji K ; Herath C ; Gao C ; Xu H ; Zhou Y ; Song X ; Chen S ; Chen Y ; Yang T ; Li J ; Qiao Y ; Hu S ; Yin X ; Lu Z
  • Oncotarget 2017[Mar]; 8 (12 ): 18699-18711 PMID27078843 show ga
  • A meta-analysis was performed to assess the association of coffee consumption with colorectal cancer and to investigate the shape of the association. Relevant prospective cohort studies were identified by a comprehensive search of the PubMed, Embase and Web of Science databases from their inception through August 2015. Either a random-effects model or fixed-effects model was used to compute the pooled risk estimates when appropriate. Linear and nonlinear dose-response meta-analyses were also performed. Nineteen prospective cohort studies involving 2,046,575 participants and 22,629 patients with colorectal cancer were included. The risk of colon cancer was decreased by 7% for every 4 cups per day of coffee (RR=0.93, 95%CI, 0.88-0.99; P=0.199). There was a threshold approximately five cups of coffee per day, and the inverse association for colorectal cancer appeared to be stronger at a higher range of intake. However, a nonlinear association of rectal cancer with coffee consumption was not observed (P for nonlinearity = 0.214). In conclusion, coffee consumption is significantly associated with a decreased risk of colorectal cancer at ? 5 cups per day of coffee consumption. The findings support the recommendations of including coffee as a healthy beverage for the prevention of colorectal cancer.
  • |*Coffee [MESH]
  • |*Diet [MESH]
  • |Cohort Studies [MESH]
  • |Colorectal Neoplasms/*epidemiology [MESH]
  • |Humans [MESH]
  • |Prospective Studies [MESH]


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