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10.1038/cddis.2017.93 http://scihub22266oqcxt.onion/10.1038/cddis.2017.93 C5386583!5386583!28300826     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2017 ; 8 (3): e2676- Nephropedia Template TP {{tp|p=28300826|t=2017. Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis |pdf=|usr=}}{{28300826}} gab.com Text Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28300826 #FOAvip Inflammatory responses involving microglia and astrocytes contribute to the pathogenesis of neurodegenerative diseases (NDs). In addition, inflammation is tightly linked to iron metabolism dysregulation. However, it is not clear whether the brain inflammation-induced iron metabolism dysregulation contributes to the NDs pathogenesis. Herein, we demonstrate that the expression of the systemic iron regulatory hormone, hepcidin, is induced by lipopolysaccharide (LPS) through the IL-6/STAT3 pathway in the cortex and hippocampus. In this paradigm, activated glial cells are the source of IL-6, which was essential in the iron overload-activated apoptosis of neurons. Disrupting astrocyte hepcidin expression prevented the apoptosis of neurons, which were able to maintain levels of FPN1 adequate to avoid iron accumulation. Together, our data are consistent with a model whereby inflammation initiates an intercellular signaling cascade in which activated microglia, through IL-6 signaling, stimulate astrocytes to release hepcidin which, in turn, signals to neurons, via hepcidin, to prevent their iron release. Such a pathway is relevant to NDs in that it links inflammation, microglia and astrocytes to neuronal damage. Twit Text FOAVip Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28300826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28300826 #FOAvip English Wikipedia <ref>{{Cite pmid|28300826}}</ref> Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis #MMPMID28300826 You LH; Yan CZ; Zheng BJ; Ci YZ; Chang SY; Yu P; Gao GF; Li HY; Dong TY; Chang YZ Cell Death Dis 2017[Mar]; 8 (3): e2676- PMID28300826show ga Inflammatory responses involving microglia and astrocytes contribute to the pathogenesis of neurodegenerative diseases (NDs). In addition, inflammation is tightly linked to iron metabolism dysregulation. However, it is not clear whether the brain inflammation-induced iron metabolism dysregulation contributes to the NDs pathogenesis. Herein, we demonstrate that the expression of the systemic iron regulatory hormone, hepcidin, is induced by lipopolysaccharide (LPS) through the IL-6/STAT3 pathway in the cortex and hippocampus. In this paradigm, activated glial cells are the source of IL-6, which was essential in the iron overload-activated apoptosis of neurons. Disrupting astrocyte hepcidin expression prevented the apoptosis of neurons, which were able to maintain levels of FPN1 adequate to avoid iron accumulation. Together, our data are consistent with a model whereby inflammation initiates an intercellular signaling cascade in which activated microglia, through IL-6 signaling, stimulate astrocytes to release hepcidin which, in turn, signals to neurons, via hepcidin, to prevent their iron release. Such a pathway is relevant to NDs in that it links inflammation, microglia and astrocytes to neuronal damage. äAstrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis (epmc).pdf DeepDyve Pubget Overpricing