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10.1038/cddis.2017.92 http://scihub22266oqcxt.onion/10.1038/cddis.2017.92 C5386582!5386582!28333150     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2017 ; 8 (3): e2689- Nephropedia Template TP {{tp|p=28333150|t=2017. Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells |pdf=|usr=}}{{28333150}} gab.com Text Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28333150 #FOAvip Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of Kaiso in the growth and survival of TNBCs. Herein, we report that Kaiso depletion attenuates TNBC cell proliferation, and delays tumor onset in mice xenografted with the aggressive MDA-231 breast tumor cells. We further demonstrate that Kaiso depletion attenuates the survival of TNBC cells and increases their propensity for apoptotic-mediated cell death. Notably, Kaiso depletion downregulates BRCA1 expression in TNBC cells expressing mutant-p53 and we found that high Kaiso and BRCA1 expression correlates with a poor overall survival in breast cancer patients. Collectively, our findings reveal a role for Kaiso in the proliferation and survival of TNBC cells, and suggest a relevant role for Kaiso in the prognosis and treatment of TNBCs. Twit Text FOAVip Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28333150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28333150 #FOAvip English Wikipedia <ref>{{Cite pmid|28333150}}</ref> Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells #MMPMID28333150 Bassey-Archibong BI; Rayner LGA; Hercules SM; Aarts CW; Dvorkin-Gheva A; Bramson JL; Hassell JA; Daniel JM Cell Death Dis 2017[Mar]; 8 (3): e2689- PMID28333150show ga Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple negative tumors, and this correlates with their increased aggressiveness. However, little is known about the clinical relevance of Kaiso in the growth and survival of TNBCs. Herein, we report that Kaiso depletion attenuates TNBC cell proliferation, and delays tumor onset in mice xenografted with the aggressive MDA-231 breast tumor cells. We further demonstrate that Kaiso depletion attenuates the survival of TNBC cells and increases their propensity for apoptotic-mediated cell death. Notably, Kaiso depletion downregulates BRCA1 expression in TNBC cells expressing mutant-p53 and we found that high Kaiso and BRCA1 expression correlates with a poor overall survival in breast cancer patients. Collectively, our findings reveal a role for Kaiso in the proliferation and survival of TNBC cells, and suggest a relevant role for Kaiso in the prognosis and treatment of TNBCs. äKaiso depletion attenuates the growth and survival of triple negative (epmc).pdf DeepDyve Pubget Overpricing