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10.1038/cddis.2016.466 http://scihub22266oqcxt.onion/10.1038/cddis.2016.466 C5386457!5386457!28206986     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2017 ; 8 (2): e2614- Nephropedia Template TP {{tp|p=28206986|t=2017. In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells |pdf=|usr=}}{{28206986}} gab.com Text In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28206986 #FOAvip Nanofibrils of small molecules, as a new class of biofunctional entities, exhibit emergent properties for controlling cell fates, but the relevant mechanism remains to be elucidated and the in vivo effect has yet to be examined. Here, we show that D-peptide nanofibrils, generated by enzyme-instructed self-assembly (EISA), pleiotropically activate extrinsic death signaling for selectively killing cancer cells. Catalyzed by alkaline phosphatases and formed in situ on cancer cells, D-peptide nanofibrils present autocrine proapoptotic ligands to their cognate receptors in a juxtacrine manner, as well as directly cluster the death receptors. As multifaceted initiators, D-peptide nanofibrils induce apoptosis of cancer cells without harming normal cells in a co-culture, kill multidrug-resistant (MDR) cancer cells, boost the activities of anticancer drugs, and inhibit tumor growth in a murine model. Such a supramolecular cellular biochemical process (consisting of reaction, assembly, and binding) for multi-targeting or modulating protein?protein interaction networks ultimately may lead to new ways for combating cancer drug resistance. Twit Text FOAVip In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=28206986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28206986 #FOAvip English Wikipedia <ref>{{Cite pmid|28206986}}</ref> In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells #MMPMID28206986 Du X; Zhou J; Wang H; Shi J; Kuang Y; Zeng W; Yang Z; Xu B Cell Death Dis 2017[Feb]; 8 (2): e2614- PMID28206986show ga Nanofibrils of small molecules, as a new class of biofunctional entities, exhibit emergent properties for controlling cell fates, but the relevant mechanism remains to be elucidated and the in vivo effect has yet to be examined. Here, we show that D-peptide nanofibrils, generated by enzyme-instructed self-assembly (EISA), pleiotropically activate extrinsic death signaling for selectively killing cancer cells. Catalyzed by alkaline phosphatases and formed in situ on cancer cells, D-peptide nanofibrils present autocrine proapoptotic ligands to their cognate receptors in a juxtacrine manner, as well as directly cluster the death receptors. As multifaceted initiators, D-peptide nanofibrils induce apoptosis of cancer cells without harming normal cells in a co-culture, kill multidrug-resistant (MDR) cancer cells, boost the activities of anticancer drugs, and inhibit tumor growth in a murine model. Such a supramolecular cellular biochemical process (consisting of reaction, assembly, and binding) for multi-targeting or modulating protein?protein interaction networks ultimately may lead to new ways for combating cancer drug resistance. äIn situ generated D-peptidic nanofibrils as multifaceted apoptotic ind(epmc).pdf DeepDyve Pubget Overpricing