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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Heart+Fail+Rep
2017 ; 14
(2
): 117-126
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English Wikipedia
Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and
Clinical Implications
#MMPMID28233259
Kim YH
; Nijst P
; Kiefer K
; Tang WH
Curr Heart Fail Rep
2017[Apr]; 14
(2
): 117-126
PMID28233259
show ga
INTRODUCTION: The endothelial surface layer is covered with abundant
proteoglycans, of which syndecans and glycosaminoglycans are major constituents.
RECENT FINDINGS: Among the endothelial glycocalyx (eGC) constituents, syndecan-1
(sdc1) is a main component, and an elevated serum level of sdc1 may indicate the
degradation of eGC. In patients with ischemic heart disease or heart failure,
elevation of serum sdc1 has been associated with worsening cardiac and renal
function; however, the causal relationship between degradation of eGC and
clinical outcomes is unclear. Herein, we review the previous literature on eGC in
cardiovascular and noncardiovascular diseases and their clinical implications.