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10.1038/ncb3487 http://scihub22266oqcxt.onion/10.1038/ncb3487 C5386136!5386136!28263956     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (4): 292-305 Nephropedia Template TP {{tp|p=28263956|t=2017. SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras |pdf=|usr=}}{{28263956}} gab.com Text SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28263956 #FOAvip SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN-domain is an unexpected Ras-association domain with high affinity for GTP-bound Ras and Rap G-proteins. The role of Rap1 in integrin activation is well established but the mechanisms to antagonize it remain largely unknown. Here, we show that SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN-domain and thus limiting their bioavailability at the plasma membrane. Consistently, SHANK3 silencing triggers increased plasma membrane Rap1 activity, cell spreading, migration and invasion. Autism-related mutations within the SHANK3 SPN-domain (R12C and L68P) disrupt G-protein interaction and fail to counteract integrin activation along the Rap1/RIAM/talin axis in cancer cells and neurons. Altogether, we establish SHANKs as critical regulators of G-protein signalling and integrin-dependent processes. Twit Text FOAVip SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28263956 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28263956 #FOAvip English Wikipedia <ref>{{Cite pmid|28263956}}</ref> SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras #MMPMID28263956 Lilja J; Zacharchenko T; Georgiadou M; Jacquemet G; De Franceschi N; Peuhu E; Hamidi H; Pouwels J; Martens V; Nia FH; Beifuss M; Boeckers T; Kreienkamp HJ; Barsukov IL; Ivaska J Nat Cell Biol 2017[Apr]; 19 (4): 292-305 PMID28263956show ga SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of the SHANK3 N-terminal region revealed that the SPN-domain is an unexpected Ras-association domain with high affinity for GTP-bound Ras and Rap G-proteins. The role of Rap1 in integrin activation is well established but the mechanisms to antagonize it remain largely unknown. Here, we show that SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN-domain and thus limiting their bioavailability at the plasma membrane. Consistently, SHANK3 silencing triggers increased plasma membrane Rap1 activity, cell spreading, migration and invasion. Autism-related mutations within the SHANK3 SPN-domain (R12C and L68P) disrupt G-protein interaction and fail to counteract integrin activation along the Rap1/RIAM/talin axis in cancer cells and neurons. Altogether, we establish SHANKs as critical regulators of G-protein signalling and integrin-dependent processes. äSHANK proteins limit integrin activation by directly interacting with (epmc).pdf DeepDyve Pubget Overpricing