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10.1091/mbc.E16-10-0722 http://scihub22266oqcxt.onion/10.1091/mbc.E16-10-0722 C5385938!5385938 !28179460     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28179460 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2017 ; 28 (7 ): 890-897 Nephropedia Template TP {{tp|p=28179460 |t=2017. Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes |pdf=|usr=}}{{28179460 }} gab.com Text Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28179460 #FOAvip Recognition of surface-tethered antigens (Ags) by B-cells leads to the formation of an immune synapse that promotes Ag uptake for presentation onto MHC-II molecules. Extraction of immobilized Ags at the immune synapse of B-cells relies on the local secretion of lysosomes, which are recruited to the Ag contact site by polarization of their microtubule network. Although conserved polarity proteins have been implicated in coordinating cytoskeleton remodeling with lysosome trafficking, the cellular machinery associated with lysosomal vesicles that regulates their docking and secretion at the synaptic interface has not been defined. Here we show that the v-SNARE protein Vamp-7 is associated with Lamp-1(+) lysosomal vesicles, which are recruited and docked at the center of the immune synapse of B-cells. A decrease in Vamp-7 expression does not alter lysosome transport to the synaptic interface but impairs their local secretion, a defect that compromises the ability of B-cells to extract, process, and present immobilized Ag. Thus our results reveal that B-cells rely on the SNARE protein Vamp-7 to promote the local exocytosis of lysosomes at the immune synapse, which is required for efficient Ag extraction and presentation. Twit Text FOAVip Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28179460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28179460 #FOAvip English Wikipedia <ref>{{Cite pmid|28179460 }}</ref> Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes #MMPMID28179460 Obino D ; Diaz J ; Sáez JJ ; Ibañez-Vega J ; Sáez PJ ; Alamo M ; Lankar D ; Yuseff MI Mol Biol Cell 2017[Apr]; 28 (7 ): 890-897 PMID28179460 show ga Recognition of surface-tethered antigens (Ags) by B-cells leads to the formation of an immune synapse that promotes Ag uptake for presentation onto MHC-II molecules. Extraction of immobilized Ags at the immune synapse of B-cells relies on the local secretion of lysosomes, which are recruited to the Ag contact site by polarization of their microtubule network. Although conserved polarity proteins have been implicated in coordinating cytoskeleton remodeling with lysosome trafficking, the cellular machinery associated with lysosomal vesicles that regulates their docking and secretion at the synaptic interface has not been defined. Here we show that the v-SNARE protein Vamp-7 is associated with Lamp-1(+) lysosomal vesicles, which are recruited and docked at the center of the immune synapse of B-cells. A decrease in Vamp-7 expression does not alter lysosome transport to the synaptic interface but impairs their local secretion, a defect that compromises the ability of B-cells to extract, process, and present immobilized Ag. Thus our results reveal that B-cells rely on the SNARE protein Vamp-7 to promote the local exocytosis of lysosomes at the immune synapse, which is required for efficient Ag extraction and presentation. |Animals [MESH] |Antigen Presentation/immunology [MESH] |Antigens/metabolism [MESH] |B-Lymphocytes/*metabolism/physiology [MESH] |Cell Line [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Exocytosis [MESH] |Lysosomes/metabolism [MESH] |Mice [MESH] |Protein Transport [MESH] |R-SNARE Proteins/*metabolism/*physiology [MESH] |SNARE Proteins/metabolism [MESH]Vamp-7-dependent secretion at the immune synapse regulates antigen ext(epmc).pdf DeepDyve Pubget Overpricing