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10.1155/2017/4702067 http://scihub22266oqcxt.onion/10.1155/2017/4702067 C5385915!5385915 !28428961     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28428961 &cmd=llinks): Failed to open stream: HTTP request failed! 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Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis |pdf=|usr=}}{{28428961 }} gab.com Text Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28428961 #FOAvip Uncoupling protein 2 (UCP2) may be critical for intestinal barrier function which may play a key role in the development of sepsis, and insulin has been reported to have anti-inflammatory effects. Male Sprague-Dawley rats were randomly allocated into five groups: control group, cecal ligation and puncture (CLP) group, sham surgery group, CLP plus glucose-insulin-potassium (GIK) group, and CLP plus glucose and potassium (GK) group. Ileum tissues were collected at 24?h after surgery. Histological and cytokine analyses, intestinal permeability tests, and western blots of intestinal epithelial tight junction component proteins and UCP2 were performed. Compared with CLP group, the CLP + GIK group had milder histological damage, lower levels of cytokines in the serum and ileum tissue samples, and lower UCP2 expression, whereas the CLP + GK group had no such effects. Moreover, the CLP + GIK group exhibited decreased epithelial permeability of the ileum and increased expression of zonula occludens-1, occludin, and claudin-1 in the ileum. The findings demonstrated that the UCP2 and NLR family-pyrin domain-containing 3/caspase 1/interleukin 1? signaling pathway may be involved in intestinal barrier injury and that GIK treatment decreased intestinal barrier permeability. Thus, GIK may be a useful treatment for intestinal barrier injury during sepsis. Twit Text FOAVip Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=28428961 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28428961 #FOAvip English Wikipedia <ref>{{Cite pmid|28428961 }}</ref> Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis #MMPMID28428961 Zhang JL ; Chen YT ; Chen GD ; Wang T ; Zhang JX ; Zeng QY Biomed Res Int 2017[]; 2017 (ä): 4702067 PMID28428961 show ga Uncoupling protein 2 (UCP2) may be critical for intestinal barrier function which may play a key role in the development of sepsis, and insulin has been reported to have anti-inflammatory effects. Male Sprague-Dawley rats were randomly allocated into five groups: control group, cecal ligation and puncture (CLP) group, sham surgery group, CLP plus glucose-insulin-potassium (GIK) group, and CLP plus glucose and potassium (GK) group. Ileum tissues were collected at 24?h after surgery. Histological and cytokine analyses, intestinal permeability tests, and western blots of intestinal epithelial tight junction component proteins and UCP2 were performed. Compared with CLP group, the CLP + GIK group had milder histological damage, lower levels of cytokines in the serum and ileum tissue samples, and lower UCP2 expression, whereas the CLP + GK group had no such effects. Moreover, the CLP + GIK group exhibited decreased epithelial permeability of the ileum and increased expression of zonula occludens-1, occludin, and claudin-1 in the ileum. The findings demonstrated that the UCP2 and NLR family-pyrin domain-containing 3/caspase 1/interleukin 1? signaling pathway may be involved in intestinal barrier injury and that GIK treatment decreased intestinal barrier permeability. Thus, GIK may be a useful treatment for intestinal barrier injury during sepsis. |Animals [MESH] |Caspase 1/genetics [MESH] |Coinfection/*drug therapy/microbiology/pathology [MESH] |Disease Models, Animal [MESH] |Glucose/administration & dosage [MESH] |Humans [MESH] |Inflammasomes/genetics [MESH] |Insulin/administration & dosage [MESH] |Interleukin-1beta/genetics [MESH] |Intestinal Diseases/*drug therapy/microbiology/pathology [MESH] |Intestinal Mucosa/drug effects/injuries/pathology [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*genetics [MESH] |Potassium/administration & dosage [MESH] |Pyrin Domain/genetics [MESH] |Rats [MESH] |Sepsis/*drug therapy/microbiology/pathology [MESH]Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuri(epmc).pdf DeepDyve Pubget Overpricing