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http://scihub22266oqcxt.onion/ C5385635!5385635!28401003     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Cancer+Res 2017 ; 7 (3): 448-61 Nephropedia Template TP {{tp|p=28401003|t=2017. Histone demethylase PHF8 promotes progression and metastasis of gastric cancer |pdf=|usr=}}{{28401003}} gab.com Text Histone demethylase PHF8 promotes progression and metastasis of gastric cancer JO: Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28401003 #FOAvip Histone demethylase plant homeodomain (PHD) finger protein 8 (PHF8) has been implicated in tumor development and malignant progression in various types of cancers. However, its potential roles in gastric cancer (GC) have not been explored. In this report, we show that PHF8 expression is upregulated in GC tissues, and the enhanced PHF8 level indicates a poor prognosis of GC patients. PHF8 knockdown reduces proliferation and metastasis of GC cells, while PHF8 overexpression has the opposite effects. Mechanistically, PHF8 interacts with ?-catenin, and binds to the promoter region of vimentin, leading to the promotion of vimentin transcription. In addition, we show that H. pylori, the single most important risk factor for GC, markedly induce PHF8 expression. Our results suggest that H. pylori-induced PHF8-?-catenin-vimentin axis activation is a novel mechanism for GC malignant progression. Thus, we identify PHF8 as an oncogenic factor of GC, and suggest PHF8 might be a potential molecular target for therapeutic approaches for GC. Twit Text FOAVip Histone demethylase PHF8 promotes progression and metastasis of gastric cancer ????Am J Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28401003 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28401003 #FOAvip English Wikipedia <ref>{{Cite pmid|28401003}}</ref> Histone demethylase PHF8 promotes progression and metastasis of gastric cancer #MMPMID28401003 Li S; Sun A; Liang X; Ma L; Shen L; Li T; Zheng L; Shang W; Zhao W; Jia J Am J Cancer Res 2017[]; 7 (3): 448-61 PMID28401003show ga Histone demethylase plant homeodomain (PHD) finger protein 8 (PHF8) has been implicated in tumor development and malignant progression in various types of cancers. However, its potential roles in gastric cancer (GC) have not been explored. In this report, we show that PHF8 expression is upregulated in GC tissues, and the enhanced PHF8 level indicates a poor prognosis of GC patients. PHF8 knockdown reduces proliferation and metastasis of GC cells, while PHF8 overexpression has the opposite effects. Mechanistically, PHF8 interacts with ?-catenin, and binds to the promoter region of vimentin, leading to the promotion of vimentin transcription. In addition, we show that H. pylori, the single most important risk factor for GC, markedly induce PHF8 expression. Our results suggest that H. pylori-induced PHF8-?-catenin-vimentin axis activation is a novel mechanism for GC malignant progression. Thus, we identify PHF8 as an oncogenic factor of GC, and suggest PHF8 might be a potential molecular target for therapeutic approaches for GC. äHistone demethylase PHF8 promotes progression and metastasis of gastri(epmc).pdf DeepDyve Pubget Overpricing