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10.1038/cr.2017.42 http://scihub22266oqcxt.onion/10.1038/cr.2017.42 C5385618!5385618!28337984     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2017 ; 27 (4): 505-25 Nephropedia Template TP {{tp|p=28337984|t=2017. Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor |pdf=|usr=}}{{28337984}} gab.com Text Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28337984 #FOAvip T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-specific immune responses based on various biochemical changes of CD3 cytoplasmic domains, but the underlying structural basis remains elusive. Here we developed biophysical approaches to study the conformational dynamics of CD3? cytoplasmic domain (CD3?CD). At the single-molecule level, we found that CD3?CD could have multiple conformational states with different openness of three functional motifs, i.e., ITAM, BRS and PRS. These conformations were generated because different regions of CD3?CD had heterogeneous lipid-binding properties and therefore had heterogeneous dynamics. Live-cell imaging experiments demonstrated that different antigen stimulations could stabilize CD3?CD at different conformations. Lipid-dependent conformational dynamics thus provide structural basis for the versatile signaling property of TCR. Twit Text FOAVip Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=28337984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28337984 #FOAvip English Wikipedia <ref>{{Cite pmid|28337984}}</ref> Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor #MMPMID28337984 Guo X; Yan C; Li H; Huang W; Shi X; Huang M; Wang Y; Pan W; Cai M; Li L; Wu W; Bai Y; Zhang C; Liu Z; Wang X; Zhang XF; Tang C; Wang H; Liu W; Ouyang B; Wong CC; Cao Y; Xu C Cell Res 2017[Apr]; 27 (4): 505-25 PMID28337984show ga T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-specific immune responses based on various biochemical changes of CD3 cytoplasmic domains, but the underlying structural basis remains elusive. Here we developed biophysical approaches to study the conformational dynamics of CD3? cytoplasmic domain (CD3?CD). At the single-molecule level, we found that CD3?CD could have multiple conformational states with different openness of three functional motifs, i.e., ITAM, BRS and PRS. These conformations were generated because different regions of CD3?CD had heterogeneous lipid-binding properties and therefore had heterogeneous dynamics. Live-cell imaging experiments demonstrated that different antigen stimulations could stabilize CD3?CD at different conformations. Lipid-dependent conformational dynamics thus provide structural basis for the versatile signaling property of TCR. äLipid-dependent conformational dynamics underlie the functional versat(epmc).pdf DeepDyve Pubget Overpricing